脐血干细胞移植治疗对失代偿期肝硬化患者细胞因子水平的影响及其临床意义

发布时间：2018-05-07 03:12

本文选题：脐血干细胞移植 + 失代偿期肝硬化　；参考：《华中科技大学学报(医学版)》2015年03期

【摘要】：目的探讨失代偿期肝硬化患者经脐血干细胞移植治疗后血清中细胞因子水平的变化及其临床意义。方法选取50例失代偿期肝硬化患者,经肝动脉灌注进行脐血干细胞移植治疗,采用ELISA方法检测术前及术后第8、16、24周血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、成纤维细胞生长因子-β(FGF-β)水平及肝纤维化指标的变化。结果患者在脐血干细胞移植治疗后第8周就出现肝功能好转并持续改善,第16、24周较术前明显改善,差异均有统计学意义(均P0.05);治疗后第16、24周患者血清中TNF-α、IL-6、FGF-β水平均较术前明显下降,差异均有统计学意义(均P0.05);术后第24周肝纤维化指标亦有明显改善(P0.05)。结论脐血干细胞移植治疗能改善失代偿期肝硬化患者的肝功能及降低血清TNF-α、IL-6、FGF-β等细胞因子水平,有望作为一种新的治疗失代偿期肝硬化的方法而得到推广。
[Abstract]:Objective to investigate the changes and clinical significance of serum cytokines in patients with decompensated cirrhosis after cord blood stem cell transplantation. Methods Fifty patients with decompensated cirrhosis were treated with umbilical cord blood stem cell transplantation via hepatic artery. The serum levels of tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6), fibroblast growth factor- 尾 (FGF- 尾) and hepatic fibrosis were measured by ELISA method before and after 816 weeks. Results the liver function was improved and continued to improve in the 8th week after cord blood stem cell transplantation, and significantly improved at the 16th week, 24 weeks after transplantation. The serum levels of TNF- 伪 and IL-6 FGF- 尾 in the patients at the 24th week after treatment were significantly lower than those before the operation (all P 0.05), and the liver fibrosis indexes were also significantly improved 24 weeks after treatment (P 0.05). Conclusion Cord blood stem cell transplantation can improve liver function and decrease the level of serum TNF- 伪 IL-6 and FGF- 尾 in patients with decompensated cirrhosis. It is expected to be a new method for the treatment of decompensated cirrhosis.
【作者单位】：武汉市中西医结合医院消化内科;
【基金】：湖北省自然科学基金资助项目(No.2013CFC115)
【分类号】：R575.2

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