不同浓度肝素液在重症胰腺炎患者连续肾脏替代疗法中心静脉导管封管中的应用

发布时间：2018-05-08 03:14

  本文选题：肝素盐水 + 重症急性胰腺炎　； 参考：《广东医学》2017年23期

【摘要】：目的探讨重症胰腺炎(SAP)患者连续肾脏替代疗法(CRRT)中心静脉导管封管的合理肝素浓度。方法 60例SAP采用中心静脉置管行CRRT治疗的患者随机分为3组(n=20)。A组:低浓度肝素盐水(625 U/m L),B组:中浓度肝素盐水(1 250 U/m L),C组:高浓度肝素盐水(2 500 U/m L)。监测血管通路通畅、出血情况,测定封管前、封管后2、4 h凝血指标。结果各组患者导管堵塞和出血发生情况比较,差异均无统计学意义(P0.05)。3组患者间封管前、封管后2、4 h凝血功能指标[凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、凝血酶时间(TT)]比较,差异均无统计学意义(P0.05)。3组患者封管后2、4 h凝血功能指标与封管前比较,差异均无统计学意义(P0.05)。结论低浓度肝素封管液可以用于大多数SAP患者CRRT中心静脉导管的封管,有高凝倾向的患者可能更适合采用高浓度肝素液。
[Abstract]:Objective to investigate the reasonable concentration of heparin in patients with severe pancreatitis (SAP) treated by continuous renal replacement therapy (CRRT). Methods Sixty patients with SAP treated with central venous catheterization CRRT were randomly divided into 3 groups: group A: low concentration heparin saline (625 U / m L) group: middle concentration heparin saline solution (1 250 U / m L); group C: high concentration heparin salt water (n = 2 500 U / m L). The blood coagulation indexes were measured before and 2 hours after closure. Results there was no significant difference in the incidence of catheterization and bleeding in all groups. There was no significant difference between the two groups. There was no significant difference in coagulation function between P0.05.3 group and P0.053.There was no significant difference in coagulation function between the two groups. Conclusion low concentration heparin can be used in the sealing of CRRT central venous catheter in most SAP patients, and the patients with high coagulation tendency may be more suitable for high concentration heparin solution.
【作者单位】： 南昌大学第二附属医院重症医学科;
【基金】：江西省科技计划项目(编号:20151BBG70182)
【分类号】：R576
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本文编号：1859708