和胃愈疡颗粒结合四联疗法治疗寒热错杂型幽门螺杆菌相关性消化性溃疡的临床研究

发布时间：2018-05-08 13:33

本文选题：消化性溃疡 + 幽门螺杆菌　；参考：《中药材》2017年06期

【摘要】：目的:观察和胃愈疡颗粒结合四联疗法治疗寒热错杂型幽门螺杆菌(Helicobacter pylori,Hp)相关性消化性溃疡(Peptic Ulcer,PU)的临床疗效及安全性。方法:将80例PU患者随机分为对照组和观察组,每组40例。对照组采取含铋剂四联疗法,观察组在前者基础上服用和胃愈疡颗粒,疗程持续14天。治疗后比较两组患者中医症状积分、Hp根除率及复发率、再生黏膜组织成熟度及血清表皮生长因子(EGF)含量,评价临床综合疗效及安全性。结果:两组两患者综合疗效差异无统计学意义(P0.05)。观察组在缓解临床症状、减少Hp复发率、提高再生黏膜组织成熟度及血清EGF含量作用优于对照组(P0.05)。两组在疗程结束之后并未出现明显不良反应。结论:和胃愈疡颗粒结合四联疗法治疗寒热错杂型Hp相关性PU效果确切,能提高症状缓解率,降低复发率,提高溃疡愈合率及愈合质量,具有较高的安全性。
[Abstract]:Objective: to observe the clinical efficacy and safety of Hewei Yuyang granule combined with tetralogy in the treatment of Helicobacter pylori Helicobacter pylori (Helicobacter pylori) associated peptic ulcers (peptic Ulcera). Methods: 80 patients with pu were randomly divided into control group and observation group with 40 cases in each group. The control group was treated with bismuth containing tetralogy and the observation group was treated with Hewei Yuyang granule on the basis of the former for 14 days. After treatment, the eradication rate and recurrence rate of HP, the tissue maturity of regenerated mucosa and the content of serum epidermal growth factor (EGF) were compared between the two groups, and the comprehensive clinical efficacy and safety were evaluated. Results: there was no significant difference in comprehensive curative effect between the two groups (P 0.05). In the observation group, the clinical symptoms were alleviated, the recurrence rate of HP was reduced, the maturity of regenerated mucosa tissue and the content of serum EGF were improved better than that of the control group (P 0.05). There were no significant adverse reactions in the two groups after the end of the course of treatment. Conclusion: Hewei Yuyang granule combined with tetralogy therapy is effective in treating HP related pu with cold and heat disorder. It can improve symptom relief rate, reduce recurrence rate, improve healing rate and healing quality of ulcer, and has higher safety.
【作者单位】：南京中医药大学;南京中医药大学附属常州市中医医院;
【分类号】：R573.1

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