初发型广泛型溃疡性结肠炎67例临床特征分析

发布时间：2018-05-10 13:54

本文选题：溃疡性结肠炎 + 初发型　；参考：《新疆医科大学》2014年硕士论文

【摘要】：目的：分析初发型广泛型溃疡性结肠炎(UC)的临床特征。方法：回顾性分析新疆维吾尔自治区人民医院2007年5月至2013年3月确诊为初发型UC并住院治疗患者的病历资料,比较广泛型、直肠型及左半结肠型患者的民族构成比、性别比、诊断时年龄、居住环境、疾病严重程度、临床症状、实验室检查结果、结肠镜结果及病理组织学检查结果。三组间比较时,正态分布资料采用单因素方差分析,偏态分布资料及等级资料采用Kruskal-Wallis H检验,计数资料采用卡方检验。结果：共纳入初发型广泛型UC患者67例,汉族、维吾尔族及哈萨克族的构成比分别为32.8%、58.2%、9.0%,男女性别比为1.48：1,诊断时的平均年龄为(43.27±16.91)岁,城市与农村之比为3.19：1,疾病严重程度以轻度多见,轻、中、重度各占56.7%、20.9%、22.4%。症状主要以腹痛、腹泻及黏液脓血便多见,部分患者可有发热及里急后重,少数患者伴有腹胀、恶心呕吐及外周关节炎。ESR加快、超敏CRP升高及血浆纤维蛋白原升高分别占37.3%、44.8%、31.3%。与初发型直肠型UC及初发型左半结肠型UC相比,初发型广泛型UC患者腹痛、腹泻、重度、维吾尔族多见及Mayo评分较高。且腹痛、腹泻、重度、维吾尔族及Mayo评分在三组间的两两比较中差异有统计学意义(P0.017)。结论：初发型广泛型UC以腹痛、腹泻及维吾尔族多见,Mayo评分较高,疾病严重程度以轻中度为主,与直肠型及左半结肠型比较,重度明显增多。
[Abstract]:Objective: to analyze the clinical features of UC- type ulcerative colitis. Methods: the medical records of patients with initial UC diagnosed in Xinjiang Uygur Autonomous region people's Hospital from May 2007 to March 2013 were retrospectively analyzed. The ethnic composition and sex ratio of patients with extensive type, rectum type and left hemicolon type were compared. Age, living environment, severity of disease, clinical symptoms, laboratory findings, colonoscopy and histopathological findings. The normal distribution data were analyzed by single factor ANOVA, the skewness distribution data and grade data were tested by Kruskal-Wallis H test, and the counting data were checked by chi-square test. Results: a total of 67 patients were included in this study. The constituent ratios of Han, Uygur and Kazak nationalities were 32.8and 58.29.0 respectively. The sex ratio of male to female was 1.48: 1. The average age of diagnosis was 43.27 卤16.91 years old. The ratio of urban to rural is 3.19: 1. The severity of the disease is mild, moderate and severe, accounting for 56.7% and 20.9% respectively. The main symptoms were abdominal pain, diarrhea and mucus abscess. Some of the patients had fever and aggravation. A few patients were accompanied with abdominal distension, nausea and vomiting, peripheral arthritis. ESR was accelerated. The increase of hypersensitive CRP and plasma fibrinogen accounted for 37.3% and 31.3% respectively. Compared with the initial rectal type UC and the initial left hemicolon type UC, the patients with the initial extensive UC had abdominal pain, diarrhea, severe, Uygur, and higher Mayo score. There were significant differences in abdominal pain, diarrhea, severe, Uygur and Mayo scores between the three groups (P 0.017). Conclusion: abdominal pain, diarrhea and Uygur nationality are the most common types of Uygur patients with abdominal pain. The severity of the disease is mainly mild to moderate. Compared with rectum type and left hemicolon type, the severity of UC is obviously increased.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R574.62

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