乙肝免疫球蛋白与乙肝病毒疫苗联合应用阻断乙肝母婴传播的研究

发布时间：2018-05-11 05:56

本文选题：乙肝免疫球蛋白 + 乙肝病毒疫苗　；参考：《实用妇产科杂志》2015年08期

【摘要】：目的:评价乙肝免疫球蛋白(HBIG)联合乙型肝炎病毒疫苗(HBVac)免疫预防措施阻断乙肝病毒(HBV)母婴传播的临床效果。方法:选择2002年1月至2010年1月在本院分娩的198例HBs Ag阳性母亲及其198例新生儿为研究对象,同时依据HBIG接种方式的不同将孕妇分为研究组和对照组。研究组126例,于孕期的第28、32、36周分别肌内注射HBIG 200 U;新生儿出生后分别于出生后12小时和30天肌内注射HBIG 200 U,出生当天、第1个月和第6个月各接种5μg HBVac。对照组72例,在孕期不注射HBIG,其新生儿接种方法同研究组。结果:研究组和对照组分娩新生儿的HBV感染率分别为0.79%和2.78%,差异无统计学意义(校正χ2=0.245,P0.05);且HBe Ag(+)母亲所生孩子比HBe Ag(-)母亲所生孩子HBV感染率有增高的趋势,但无差异无统计学意义(4.65%vs.0.65%,校正χ2=1.433,P0.05)。结论:孕妇孕晚期使用HBIG对HBV母婴传播和新生儿对HBVac的抗体应答无明显影响,其中HBs Ag单阳性孕妇的阻断率有高于HBs Ag和HBe Ag双阳性孕妇的趋势。
[Abstract]:Objective: to evaluate the clinical effect of hepatitis B immunoglobulin (HBG) combined with hepatitis B virus vaccine (HBV) on blocking mother-to-child transmission of hepatitis B virus (HBV). Methods: 198cases of HBs Ag positive mothers and their newborns were selected from January 2002 to January 2010, and the pregnant women were divided into study group and control group according to the different inoculation methods of HBIG. In the study group, intramuscular injection of HBIG 200U was performed at the 28th week of gestation and intramuscular injection of HBIG 200U at 12 hours and 30 days after birth, respectively, and 5 渭 g HBVacs were inoculated on the day of birth, the first month and the sixth month, respectively. In the control group, 72 cases were not injected with HBIGduring pregnancy, and the neonatal inoculation method was the same as that in the study group. Results: the infection rate of HBV was 0.79% in the study group and 2.78% in the control group. There was no significant difference (adjusted 蠂 ~ 2 / 0.245) (P 0.05), and the HBV infection rate of the children born to the HBe Ag() mothers was higher than that of the children born to the HBe Ag-mothers. However, there was no significant difference between the two groups (4.65 vs 0.65, 蠂 ~ 2 = 1.433P 0.05). Conclusion: the use of HBIG in late pregnancy has no significant effect on HBV mother-to-child transmission and neonatal antibody response to HBVac. The blocking rate of HBs Ag single positive pregnant women is higher than that of HBs Ag and HBe Ag double positive pregnant women.
【作者单位】：四川省达州市中西医结合医院;
【分类号】：R512.62

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