血必净辅助治疗消化道恶性肿瘤相关性腹膜炎的临床疗效及安全性评价

发布时间：2018-05-11 17:34

本文选题：消化道恶性肿瘤 + 血必净　；参考：《中国临床药理学杂志》2015年09期

【摘要】：目的评价血必净对消化道恶性肿瘤相关性腹膜炎的临床疗效与安全性。方法入选消化道恶性肿瘤相关性腹膜炎60例,并随机分为试验组28例及对照组32例。对照组给予单纯抗生素治疗,试验组在对照组治疗的基础上予以血必净注射液50 mL,每日2次,疗程7 d,比较治疗前后2组的临床疗效及治疗前后的白细胞计数,C反应蛋白、降钙素原水平、肿瘤坏死因子α、白介素-6水平变化。结果试验组有效率为92.85%,对照组有效率为68.75%,试验组临床症状改善明显。2组患者治疗后较治疗前白细胞计数、C反应蛋白、降钙素原水平、肿瘤坏死因子α、白介素-6水平均显著降低(P0.05),且试验组用药7 d后上述指标水平均低于对照组(P0.05)。试验组出现2例皮肤瘙痒,对照组未有明显不良反应。结论血必净对消化道肿瘤相关性腹膜炎在降低白细胞计数、C反应蛋白、肿瘤坏死因子α、降钙素元水平及白介素-6,同时能有效改善患者发热、腹胀、腹痛等不适症状。
[Abstract]:Objective to evaluate the clinical efficacy and safety of Xuebijing in the treatment of malignant tumor-associated peritonitis of digestive tract. Methods 60 patients with malignant tumor-associated peritonitis of digestive tract were randomly divided into trial group (n = 28) and control group (n = 32). The control group was treated with antibiotics alone, and the experimental group was treated with Xuebijing injection 50 mL twice a day for 7 days. The clinical efficacy of the two groups before and after treatment and the white blood cell count before and after treatment were compared. Changes of procalcitonin level, tumor necrosis factor 伪 and interleukin -6 levels. Results the effective rate was 92.85 in the trial group and 68.75 in the control group. The clinical symptoms of the experimental group were significantly improved after treatment. The leukocyte count of C reactive protein and procalcitonin levels were significantly higher in the trial group than in the pre-treatment group. The levels of tumor necrosis factor 伪 and interleukin-6 were significantly lower in the test group than those in the control group. There were 2 cases of pruritus in the experimental group and no obvious adverse reaction in the control group. Conclusion Xuebijing can reduce leukocyte count, tumor necrosis factor 伪, calcitonin level and interleukin-6 in digestive tract tumor-associated peritonitis, and can effectively improve the symptoms of fever, abdominal distension and abdominal pain.
【作者单位】：新疆医科大学附属中医医院肿瘤二科;兰州军区乌鲁木齐市总医院肿瘤科;新疆石河子大学第一附属医院普外科;
【基金】：科技支疆计划基金资助项目(2013AB025)
【分类号】：R735;R572.2

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