不同体质量人群中碳酸饮料与非酒精性脂肪肝的关系

发布时间：2018-05-11 20:15

本文选题：碳酸饮料 + 非酒精性脂肪肝　；参考：《营养学报》2017年05期

【摘要】：目的在不同身体质量水平的成年人群中评价碳酸饮料饮用频度和非酒精性脂肪肝(NAFLD)之间的关联。方法对在天津医科大学总医院健康管理中心进行体检的20,020名成年人进行横断面调查。使用经信度效度检验过的食物频率问卷评估饮食摄入量,用腹部超声检查和谷丙转氨酶诊断NAFLD。按照体质指数标准将人群分为体质量正常组、超重组和肥胖组,采用logistics回归分析不同身体质量人群中碳酸饮料饮用频率和NAFLD患病率之间的关系。结果经调整混杂因素后,碳酸饮料饮用频率从低到高组中,体重正常组、超重组和肥胖组人群中NAFLD患者与非患者不同程度碳酸盐饮料暴露的比值比(95%置信区间)分别为1.00、0.93(0.68,1.25)、1.51(1.16,1.96)(趋势性P0.01);1.00、1.16(0.99,1.37)、1.15(0.99,1.34)(趋势性P=0.04);和1.00、1.33(1.03,1.74)、1.31(1.04,1.66)(趋势性P=0.02)。结论经调整混杂因素后,在体质量正常组和肥胖组中人群中,碳酸饮料饮用频度和NAFLD患病率相关。今后的研究中,需要更多的队列研究来确认碳酸饮料和NAFLD之间的因果关系。
[Abstract]:Objective to evaluate the association between drinking frequency of carbonated beverages and NAF LDD in adults with different body mass levels. Methods A cross-sectional investigation was carried out among 20020 adults who underwent physical examination in the Health Management Center of General Hospital of Tianjin Medical University. Dietary intake was evaluated by a reliability and validity test food frequency questionnaire, and NAFLD was diagnosed by abdominal ultrasound and alanine aminotransferase. According to the body mass index standard, the population was divided into normal body mass group, superrecombinant group and obesity group. Logistics regression analysis was used to analyze the relationship between the frequency of carbonated drink drinking and the prevalence of NAFLD in different body mass population. Results after adjusting the confounding factors, the drinking frequency of carbonated drinks ranged from low to high, and the weight was normal. The ratio of exposure of NAFLD patients to non-patients in different degrees of carbonate beverage exposure was 1.00 / 95% confidence interval (95% confidence interval), respectively. The ratio of exposure of NAFLD patients to non-patients was 1.000.93 / 1.65 / 1.161.96 / 1.96 (P 0.01 / 1.161.001.160.99 / 1.37 / 1.150.991.34 / 1.0.04; and 1.001.331.3331.031.741.741.66 / 1.66) respectively. Conclusion after adjusting for confounding factors, the frequency of drinking carbonated drinks is related to the prevalence of NAFLD in normal and obese population. In future studies, more cohort studies are needed to identify causality between carbonated beverages and NAFLD.
【作者单位】：天津医科大学营养流行病学研究所公共卫生学院;天津医科大学总医院健康管理中心;
【基金】：天津市科技支撑计划重点项目(No.11ZCGYSY05700,12ZCZDSY20400,13ZCZDSY20200)
【分类号】：R575.5

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