血清细胞因子与肝硬化腹水感染关系分析

发布时间：2018-05-12 20:03

  本文选题：肝硬化 + 腹水　； 参考：《中华医院感染学杂志》2016年06期

【摘要】：目的研究血清细胞因子与肝硬化腹水感染的关系,为感染的预防和治疗提供参考依据。方法选取2013年6月-2014年12月于医院进行治疗的38例肝硬化腹水感染患者为感染组,同期的38例肝硬化腹水未发生感染患者为非感染组,38名健康人员为正常组,将3组受试人员的血清细胞因子水平进行比较,同时比较感染组和非感染组中轻度、中度和重度腹水患者的检测结果,以logistic分析上述指标与肝硬化腹水感染的关系。结果感染组患者血清细胞因子包括白介素6(IL-6)、白介素8(IL-8)、γ-干扰素(IFN-γ)及肿瘤坏死因子α(TNF-α)水平分别为(14.52±1.89)pg/ml、(16.64±1.99)pg/ml、(23.84±2.46)ng/L及(3.89±0.37)ng/ml,其均高于非感染组及正常组,非感染组则高于正常组;感染组轻度、中度、重度腹水者的检测水平均高于非感染组,经logistic分析显示,上述血清指标均与肝硬化腹水感染有密切的关系,差异有统计学意义(P0.05)。结论肝硬化腹水感染患者的血清细胞因子呈现高表达状态,应加强对该类患者血清细胞因子的监测及干预。
[Abstract]:Objective to study the relationship between serum cytokines and ascites infection in cirrhotic patients. Methods from June 2013 to December 2014, 38 patients with cirrhotic ascites infection were selected as infection group, 38 patients without ascites infection as non-infection group, 38 healthy people as normal group, who were treated in hospital from June 2013 to December 2014. The levels of serum cytokines in the three groups were compared, and the results of mild, moderate and severe ascites were compared between the infected group and the non-infected group. The relationship between the above indexes and ascites infection in cirrhosis was analyzed by logistic. Results the levels of serum cytokines, including IL-6, IL-8, IFN- 纬, IFN- 纬 and TNF- 伪 in infected patients were 14.52 卤1.89pg / ml, 16.64 卤1.99g / ml, 23.84 卤2.46)ng/L and 3.89 卤0.37ngr / ml, respectively, which were higher than those in the non-infected group and the normal group, and were higher in the non-infected group than in the normal group. The detection level of severe ascites was higher than that of non-infection group. Logistic analysis showed that the above serum indexes were closely related to ascites infection of liver cirrhosis, and the difference was statistically significant (P 0.05). Conclusion the serum cytokines in patients with ascites infection due to cirrhosis are highly expressed, so the monitoring and intervention of serum cytokines in patients with ascites infection should be strengthened.
【作者单位】： 郑州大学附属洛阳市中心医院消化内科;
【基金】：河南省卫生厅重点基金资助项目(20120890)
【分类号】：R575.2
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本文编号：1879964