Fibroscan诊断肝纤维化分期的Meta分析

发布时间：2018-05-15 12:52

  本文选题：肝纤维化 + 瞬时弹性成像　； 参考：《中华消化病与影像杂志(电子版)》2017年04期

【摘要】：目的通过与肝活检(金标准)对比,系统评价Fibroscan诊断肝纤维化分期的准确性。方法计算机检索Pubmed、Embase、中国知网、万方数据知识服务平台及中国生物医学文献数据库中已发表的关于Fibroscan诊断肝纤维化分期的中、英文文献,检索时限为2003年1月至2016年1月,对所选文献进行筛选和评价,应用Stata14.0软件中双变量混合效应模型进行数据分析。结果所得文献经过去重、阅读题目、摘要、通读全文逐步剔除后,最终纳入37篇文献,共9167例患者。其中中文文献4篇,英文文献33篇,时间跨度为2005年1月至2015年10月。结果显示:(1)Fibro Scan诊断轻微肝纤维化(F≥1)的合并灵敏度(Sen)、特异度(Sep)、阳性似然比(PPV)、阴性似然比(NPV)、诊断比值比(OR)及SROC曲线下面积(AUC)分别为0.76、0.80、3.9、0.30、13、0.85;(2)Fibro Scan诊断明显肝纤维化(F≥2)的Sen、Sep、PPV、NPV、OR及AUC分别为0.77、0.84、4.7、0.28、17、0.88;(3)Fibro Scan诊断严重肝纤维化(F≥3)的Sen、Sep、PPV、NPV、OR及AUC分别为0.84、0.87、6.3、0.19、34、0.92;(4)Fibro Scan诊断早期肝硬化(F≥4)的Sen、Sep、PPV、NPV、OR及AUC分别0.89、0.89、8.2、0.12、67、0.95。结论 Fibroscan对肝纤维化分期、尤其是对严重肝纤维化及早期肝硬化的诊断准确性较高。
[Abstract]:Objective to evaluate the accuracy of Fibroscan in the diagnosis of hepatic fibrosis stage by comparing with liver biopsy (gold standard). Methods the published Chinese and English literatures published in Pubmedus Embase, China knowledge Network, Wanfang data knowledge Service platform and Chinese Biomedical Literature Database on the diagnosis of hepatic fibrosis staging by Fibroscan were searched by computer. The retrieval time was from January 2003 to January 2016. The selected literatures were screened and evaluated, and the data were analyzed by using the two-variable mixed effect model in Stata14.0 software. Results 9167 patients were included in 37 articles after removing the weight, reading title, abstracts, and reading the full text step by step. There are 4 articles in Chinese and 33 in English, covering the period from January 2005 to October 2015. The results showed that the combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic ratio and area under the SROC curve were 0.760.803.90.30130.85 Scan for diagnosis of liver fibrosis (F 鈮，

本文编号：1892541