氟哌噻吨美利曲辛联合雷贝拉唑治疗反流性食管炎的临床观察

发布时间：2018-05-18 13:10

本文选题：反流性食管炎 + 雷贝拉唑　；参考：《中国药房》2015年06期

【摘要】：目的:观察氟哌噻吨美利曲辛联合雷贝拉唑治疗反流性食管炎的临床疗效和安全性。方法:58例反流性食管炎患者随机分为对照组和观察组,每组29例。对照组患者给予雷贝拉唑钠肠溶片10 mg,每日2次,早上、睡前30 min口服;观察组患者在对照组治疗的基础上给予氟哌噻吨美利曲辛片1片,每日1次,早上10点口服。两组患者疗程均为8周。观察两组患者临床疗效,治疗前后临床症状总评分,汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,两组比较差异有统计学意义(P0.05)。治疗前两组患者临床症状总评分、HAMA评分、HAMD评分比较,差异均无统计学意义(P0.05);治疗后两组患者临床症状总评分、HAMA评分、HAMD评分均显著低于同组治疗前,且观察组低于对照组,差异均有统计学意义(P0.05或P0.01)。两组患者治疗期间均未见明显不良反应发生。结论:氟哌噻吨美利曲辛联合雷贝拉唑治疗反流性食管炎较单用雷贝拉唑疗效更显著,且安全性相似。
[Abstract]:Objective: to observe the clinical efficacy and safety of droperazidone and rabeprazole in the treatment of reflux esophagitis. Methods 58 patients with reflux esophagitis were randomly divided into control group and observation group with 29 cases in each group. The patients in the control group were given 10 mg of rabeprazole sodium enteric-coated tablets twice a day, 30 min before bedtime, and the patients in the observation group were given one tablet of droperidol tiadon metroxine tablet once a day at 10:00 in the morning on the basis of treatment in the control group. The course of treatment was 8 weeks. The clinical efficacy, the total score of clinical symptoms, the scores of Hamilton anxiety scale (Hama) and Hamilton Depression scale (Hamd) before and after treatment and the occurrence of adverse reactions were observed. Results: the total effective rate in the observation group was significantly higher than that in the control group, and the difference between the two groups was statistically significant (P 0.05). There was no significant difference in Hama and Hamd scores between the two groups before treatment, and after treatment, the Hama and Hamd scores of the two groups were significantly lower than those of the same group and the observation group was lower than that of the control group. The difference was statistically significant (P 0.05 or P 0.01). No significant adverse reactions occurred during treatment in both groups. Conclusion: the efficacy and safety of droperidazole combined with rabeprazole in the treatment of reflux esophagitis is more significant than that of rabeprazole alone.
【作者单位】：上海市嘉定区中医医院药剂科;上海市嘉定区中医医院消化科;
【分类号】：R571

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