从太阴病论治乙型肝炎后肝硬化代偿期患者肠道微生态的临床研究

发布时间：2018-05-19 05:18

本文选题：太阴病 + 乙型肝炎后肝硬化　；参考：《辽宁中医杂志》2016年11期

【摘要】：目的:观察理中汤治疗乙型肝炎后肝硬化代偿期患者肠道微生态的临床疗效。方法:将100例乙型肝炎后肝硬化患者随机分为治疗组52例和48对照组例,治疗组给予理中汤联合恩替卡韦分散片治疗,对照组仅予恩替卡韦分散片治疗,疗程为3个月,观察治疗前后患者肝功能、肠道菌群变化、症状积分及血清内毒、HBV-DNA转阴、HBe-Ag转阴,并探讨其可能作用机制。结果:经过理中汤治疗3个月后,治疗组患者肠道菌群变化、症状积分及血清内毒素均比对照组患者有所改善(P0.05),但在肝功能的改善及HBV-DNA转阴、HBe-Ag转阴方面没有明显区别。结论:理中汤可显著改善太阴病脾阳虚证乙型肝炎后肝硬化患者胃肠道症状及内毒素水平,其可能通过改善肝硬化患者的肠道微生态发挥作用。
[Abstract]:Objective: To observe the clinical effect of Lizhong Decoction on the intestinal microflora of patients with decompensated hepatitis B after hepatitis B. Methods: 100 cases of post hepatitis B cirrhosis were randomly divided into 52 cases in the treatment group and 48 control groups. The treatment group was treated with Lizhong decoction combined with Entecavir Dispersible Tablets, and the control group was only treated with Entecavir Dispersible Tablets, the course of treatment was 3. Before and after treatment, the liver function, intestinal flora, symptom integral and serum endotoxin, HBV-DNA turning Yin, HBe-Ag turned to Yin were observed before and after treatment. Results: after 3 months of treatment, the changes of intestinal flora, symptom integral and blood serum endotoxin were improved (P0.05) in the treatment group (P0.05), but in the liver, but in the liver There is no obvious difference between the function improvement and HBV-DNA turning Yin, and there is no obvious difference between HBe-Ag and Yin. Conclusion: Lizhong decoction can significantly improve the gastrointestinal symptoms and endotoxin level of patients with liver cirrhosis after hepatitis B syndrome, which may be used to improve the intestinal microflora of patients with liver cirrhosis.
【作者单位】：柳州市中医院;广西中医药大学研究生学院;
【基金】：广西壮族自治区柳州市科技局攻关课题(2014J030414)
【分类号】：R512.62;R575.2

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