厦门地区献血者戊肝病毒感染研究

发布时间：2018-05-19 11:06

  本文选题：戊肝病毒 + 献血者　； 参考：《中国输血杂志》2017年03期

【摘要】：目的研究献血者戊肝病毒感染情况。方法对厦门地区部分献血者标本进行戊肝病毒抗原(HEV-Ag)、抗体(HEV-IgG和HEV-IgM)检测,HEV-Ag阳性和HEV-IgM阳性者进行HEV核酸检测,核酸检测阳性标本进行序列测定和基因型分析。结果总共6 263人份献血者标本中,检出1 447例HEV-IgG阳性(1 447/6 263,23.10%)、42例HEV-IgM阳性(42/6 263,0.67%)、12例HEV-Ag阳性(12/6 263,0.19%);12例HEV-Ag阳性标本中检出8例HEV核酸阳性(8/6 263,0.13%),42例HEV-IgM阳性标本中未检出HEV核酸阳性。8例HEV核酸阳性有4例测序成功,分别为2例Ⅰ型、2例Ⅳ型。随访显示大部分阳性献血者HEV病毒血症可较长时间持续存在。结论厦门地区献血者戊肝病毒现症感染率较高,在今后的输血保障工作中应引起重视。HEV-IgM检测对献血者HEV现症感染的检出率较低,而HEV-Ag的检出率较高且同HEV核酸检测具有较高的一致性,有望在血液筛查中得以推广。
[Abstract]:Objective to study the infection of hepatitis E virus in blood donors. Methods Hepatitis E virus antigens (HEV-AgN), HEV-IgG and HEV-IgM were used to detect HEV nucleic acid in some blood donors in Xiamen area. The nucleic acid sequences and genotypes were analyzed in the positive samples. Results out of a total of 6 263 blood donors, Of the 1 447 HEV-IgG positive specimens, 1 447 HEV-IgM positive cases were detected in 1447 / 6263C 23.101010 cases and 42 cases were HEV-IgM positive 42 / 6 263C 0.670.67 + 12 HEV-Ag positive samples were detected. 8 HEV nucleic acid positive samples were detected in 8 HEV nucleic acid positive samples, and 8 HEV nucleic acid positive cases were detected in 4 out of 42 HEV-IgM positive samples, 4 of them were sequenced successfully, and 4 of the 12 HEV-Ag positive samples were positive for HEV nucleic acid. The results showed that the HEV nucleic acid was positive in 4 out of the 12 HEV-Ag positive samples, and 4 of the 12 HEV-Ag positive samples were positive for HEV nucleic acid and HEV nucleic acid, 4 of them were sequenced. There were 2 cases of type 鈪，

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