健康体检人群糖化血红蛋白水平与非酒精性脂肪肝的相关性

发布时间：2018-05-22 09:17

本文选题：非酒精性脂肪肝 + 糖化血红蛋白　；参考：《中南大学学报(医学版)》2017年05期

【摘要】：目的:探讨健康体检人群中非酒精性脂肪肝与糖化血红蛋白(glycosylated hemoglobin,Hb A1c)的关系。方法:选取符合入选条件的香港大学深圳医院体检中心2013年6月至11月的912名健康体检者作为研究对象,分为非酒精性脂肪肝组、其他肝病组和对照组,对其体检结果进行回顾性分析。结果:非酒精性脂肪肝患病率为29.7%;非酒精性脂肪肝组的年龄、体重指数、收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、空腹血糖、Hb A1c及谷丙转氨酶均高于其他肝病组和对照组(P0.05),谷草转氨酶高于对照组(P0.05),高密度脂蛋白胆固醇则低于其他肝病组和对照组(P0.05);根据Hb A1c水平的四分位数进行分层,分为Q1~Q4组,Q1,Q2,Q3及Q4组非酒精性脂肪肝患病率分别为17.5%,21.5%,31%及59.4%,随着Hb A1c水平的增高非酒精性脂肪肝的患病率逐渐增高(χ2=100.092,P0.05);logistic回归分析结果显示在校正年龄、性别、体重指数等因素后,Q4组的非酒精性脂肪肝患病风险仍高于Q1组。结论:非酒精性脂肪肝患病率与Hb A1c水平呈正相关,随着Hb A1c水平的增加而增高,高Hb A1c水平可能是非酒精性脂肪肝患病的一个独立危险因素,应将其列为健康体检常规检查项目。
[Abstract]:Objective: To investigate the relationship between nonalcoholic fatty liver and glycosylated hemoglobin (Hb A1c) in healthy people. Methods: 912 healthy persons from June 2013 to November in Shenzhen Hospital of University of Hong Kong were selected as the subjects and divided into non alcoholic fatty liver group, other liver disease group and other liver disease group. The results of non-alcoholic fatty liver disease were 29.7%. The age, body mass index, systolic blood pressure, diastolic pressure, total cholesterol, three acyl glycerol, low density lipoprotein cholesterol, fasting blood glucose, Hb A1c and alanine transaminase were higher than those of other liver and control groups (P0.05). The gluten transaminase was higher than that of the control group (P0.05), and the high density lipoprotein cholesterol was lower than that of other liver disease group and control group (P0.05); according to the four digits of Hb A1c level, it was divided into Q1~Q4 group, Q1, Q2, Q3 and Q4 group non-alcoholic fatty liver disease rates were 17.5%, 21.5%, 31% and 59.4% respectively, with Hb A1c increased non-alcoholic fatty liver. The incidence of the disease increased gradually (x 2=100.092, P0.05). The logistic regression analysis showed that the risk of non-alcoholic fatty liver disease in group Q4 was still higher than that in group Q1 after the correction of age, sex and body mass index. Conclusion: the incidence of non-alcoholic fatty liver disease is positively correlated with the level of Hb A1c, with the increase of Hb A1c level and high Hb A1c level. It may be an independent risk factor for the prevalence of nonalcoholic fatty liver disease. It should be listed as a routine physical examination item.
【作者单位】：香港大学深圳医院体检中心;中国医学科学院肿瘤医院深圳医院体检中心;南方医科大学深圳医院健康管理中心;
【分类号】：R575.5

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