重复测量分析脐带间充质干细胞移植治疗肝硬化的疗效

发布时间：2018-05-23 21:04

  本文选题：脐带 + 间质干细胞移植　； 参考：《中国组织工程研究》2015年19期

【摘要】：背景:国内外已有应用间充质干细胞治疗肝硬化的临床研究且取得了可喜的进步,但在实际应用中,经常会误用t检验分析这类资料。目的:采用重复测量方法分析脐带间充质干细胞治疗肝硬化患者的有效性和安全性。方法:失代偿性肝硬化患者27例,均行常规内科治疗,包括护肝、对症治疗等。在入院1周后静脉移植脐带间充质干细胞(第2-4代),细胞存活率≥90%,干细胞数量≥2×107个,共治疗4次,每次间隔5-7 d。使用重复测量方差分析脐带间充质干细胞移植治疗不同时点的肝功能变化。结果与结论:单变量重复测量方差分析结果显示,在治疗后2,3个月时血清白蛋白升高、总胆红素降低,与治疗前比较差异有显著性意义(P0.05);治疗后3个月,谷草转氨酶降低、胆碱酯酶升高,与治疗前比较差异有显著性意义(P0.05),所有患者在观察期内无肝脏及其他器官肿瘤发生。结果表明脐带间充质干细胞移植治疗肝硬化安全有效,患者肝功能得到改善。
[Abstract]:Background: mesenchymal stem cells (MSCs) have been used in the treatment of liver cirrhosis in China and abroad and have made gratifying progress. However, t test is often misused to analyze this kind of data in practical application. Objective: to analyze the efficacy and safety of umbilical cord mesenchymal stem cells in the treatment of patients with liver cirrhosis. Methods: 27 patients with decompensated cirrhosis were treated with routine medical treatment, including liver protection and symptomatic treatment. One week after admission, umbilical cord mesenchymal stem cells were transplanted via vein (2-4 passage, cell survival rate 鈮，

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