ADCY3基因多态性与脂肪肝的关联性研究

发布时间：2018-05-24 05:25

本文选题：ADCY + 基因多态性　；参考：《营养学报》2017年04期

【摘要】：目的探讨腺苷酸环化酶3(adenylate cyclase 3,ADCY3)基因多态性与脂肪肝易感性间的关系。方法采用横断面研究,以整群随机抽样的方法抽取浙江省宁波市当地常住居民1964人。采用标签SNP方法筛选ADCY3基因的12个位点。采用连接酶检测反应技术进行基因分型检测。采用多因素Logistic回归模型分析ADCY3基因多态性与脂肪肝易感性间的关系。结果在校正了年龄、性别等因素后,rs4665273位点TT基因型者患脂肪肝的危险性是CC基因型者的0.25倍(OR=0.25,95%CI=0.07~0.93);rs7593130位点CC基因型患脂肪肝的危险性是TT基因型者的3.33倍(OR=3.33,95%CI=1.16~9.56);rs1344840位点TT基因型患脂肪肝的危险性是CC基因型者的4.00倍(OR=4.00,95%CI=1.08~14.76)。结论 ADCY3基因多态性可能与脂肪肝发生风险有关。其中,rs4665273位点TT基因型是脂肪肝的保护性因素,而rs7593130位点CC基因型和rs1344840位点TT基因型是脂肪肝的危险因素。
[Abstract]:Objective to investigate the relationship between the polymorphism of adenylate cyclase 3(adenylate cyclase 3 (ADCY 3) gene and the susceptibility to fatty liver. Methods A cross-sectional study was conducted to select 1964 resident residents in Ningbo, Zhejiang province. The 12 loci of ADCY3 gene were screened by tag SNP method. The genotyping was detected by ligase assay. Multivariate Logistic regression model was used to analyze the relationship between ADCY3 gene polymorphism and fatty liver susceptibility. The result is that the age is adjusted, The risk of fatty liver in patients with TT genotype rs4665273 after sex was 0.25 times higher than that with CC genotype 0.25995. The risk of fatty liver of CC genotype was 3.33 times higher than that of TT genotype 3.3395CI1.169.5644840. The risk of fatty liver of CC genotype was 3.333 times higher than that of TT genotype. It was 4.00 times as much as that of CC genotype. Conclusion ADCY3 gene polymorphism may be associated with the risk of fatty liver. TT genotype at rs4665273 was the protective factor of fatty liver, while CC genotype at rs7593130 locus and TT genotype at rs1344840 locus were risk factors of fatty liver.
【作者单位】：杭州师范大学医学院预防医学系;
【基金】：浙江省自然科学基金青年基金(No.LQ16H260002) 杭州市社会发展自主申报项目(No.20160533B02)
【分类号】：R575.5

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