大黄附子汤联合双歧三联活菌胶囊治疗慢性复发型结肠炎的临床研究

发布时间：2018-05-25 16:17

本文选题：大黄附子汤 + 慢性结肠炎　；参考：《时珍国医国药》2017年08期

【摘要】：目的观察大黄附子汤联合双歧三联活菌胶囊对慢性复发型结肠炎患者的临床疗效。方法从常州市中医医院、南京中医药大学附属医院和苏州市中医医院肛肠科门诊病人中选取符合纳入标准的患者90例,随机数字表法分为治疗A组(口服双歧三联活菌胶囊,2粒/次,3次/d)30例,治疗B组(在治疗A组基础上,口服大黄附子汤,早晚各1次)30例和对照组(美沙拉嗪缓释颗粒剂,1 g/次,3次/d)30例,三组疗程均为3个月。比较三组治疗前后临床疗效,粪钙卫蛋白、C反应蛋白和红细胞沉降率的变化趋势,炎症性肠病评价量表评分、停药1个月后的复发率及不良反应。结果与对照组相比,治疗B组在临床综合疗效,粪钙卫蛋白、C反应蛋白和红细胞沉降率、停药1个月后复发率方面经统计学比较均有明显差异(P0.05,P0.01)。结论大黄附子汤联合双歧三联活菌胶囊治疗慢性复发型结肠炎患者临床疗效显著,且无明显不良反应,值得临床推广应用。
[Abstract]:Objective to observe the clinical effect of rhubarb and aconite decoction combined with Bifidobacterium triple viable capsule on chronic recurrent colitis. Methods from Changzhou traditional Chinese Medicine Hospital, affiliated Hospital of Nanjing University of traditional Chinese Medicine and Suzhou Hospital of traditional Chinese Medicine, 90 patients who met the inclusion criteria were selected. Randomly divided into treatment group A (oral bifidobacterium trisodium live bacteria capsule 2 / 3 times / 3 times / d) 30 cases, treatment group B (on the basis of treatment group A, oral Dahuang aconite decoction, There were 30 cases in the morning and evening and 30 cases in the control group. The treatment course of the three groups was 3 months. The clinical efficacy, the change trend of fecal calcitonin C reactive protein and erythrocyte sedimentation rate, the evaluation scale of inflammatory bowel disease, the recurrence rate and adverse reaction after one month were compared between the three groups. Results compared with the control group, there were significant differences in clinical efficacy, fecal calcitonin C reactive protein, erythrocyte sedimentation rate and recurrence rate after one month after withdrawal in group B. Conclusion Dahuang Fuzi decoction combined with Bifidobacterium Trifolium capsule is effective in the treatment of chronic recurrent colitis, and has no obvious adverse reactions, so it is worth popularizing.
【作者单位】：江苏省常州市中医医院;南京中医药大学附属医院;江苏省苏州市中医医院;
【基金】：江苏省中医药局课题(No.JD11005)
【分类号】：R574.62

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