丙型肝炎病毒感染和冠状动脉粥样硬化性疾病发病风险的meta分析

发布时间：2018-05-26 00:23

本文选题：丙型肝炎病毒 + 冠状动脉疾病　；参考：《重庆医科大学》2017年硕士论文

【摘要】：目的:评价丙型肝炎肝病毒感染是否是粥样硬化性疾病的危险因素。方法:检索了中文科技期刊全文数据库、万方数据库、pubmed、cochrance、scopus、Embase数据库、中国生物医学数据库等数据库。严格按下文所述纳入排除标准,收集丙型肝炎病毒感染与冠状动脉粥样硬化性疾病发病风险的相关研究。采用Newcastle-Ottawa质量评价量表进行质量评价,利用Comprehensive Meta-Analysis version 2.0软件进行数据分析,绘制森林图,并进行亚组分析。结果:共纳入13项关于丙型肝炎病毒感染与冠状动脉粥样硬化性相关疾病发病风险的研究。meta分析发现,丙型肝炎病毒患者发生冠状动脉粥样硬化相关疾病风险是非丙肝患者的1.3倍,OR=1.32(CI95%,1.05-1.66,P0.05)。根据研究设计方式、年龄、糖尿病、高血压等对其进行分层分析,年龄按50岁为分组的临界值,糖尿病按流行人数的20%为分组的临界值,高血压组按流行人数的20%为临界值。结果发现年龄50岁,丙型肝炎病毒患者发生冠状动脉粥样硬化性心脏病的发病风险为1.28(95CI,1.04-1.59,P0.05),年龄50岁者总发病风险OR值为1.31(95%CI,0.94-1.82,P0.05),两组无显著性差异。20%以下患有高血压的慢性丙型肝炎患者发生冠状动脉粥样硬化性疾病的风险OR值为1.10(95%CI,0.60-1.82,P0.05),P0.05,无统计学意义。而20%以上患有高血压的丙型肝炎患者发生冠状动脉粥样硬化的风险OR值为1.39(95%CI,1.15-1.66,P0.05)。20%以下的有糖尿病的丙型肝炎患者发生冠状动脉粥样硬化性疾病的发病风险OR值为1.08(95%CI,0.60-1.96,P0.05),无统计学意义。20%以上有糖尿病的丙型肝炎患者发生冠状动脉粥样硬化性疾病的风险OR值为1.35(95%CI,1.08-1.68,P0.05)。结论:丙型肝炎病毒感染可以显著增加冠状动脉粥样硬化性心脏病的发病风险。
[Abstract]:Objective: to evaluate whether hepatitis C virus infection is a risk factor for atherosclerosis. Methods: the full text database of Chinese scientific and technological journals, the database of pubmeda cochranceus Embase, the database of Chinese biomedicine and so on were searched. Research on the risk of hepatitis C virus infection and coronary atherosclerotic disease was collected strictly according to the exclusion criteria described below. The Newcastle-Ottawa quality evaluation scale was used to evaluate the quality, the data was analyzed by Comprehensive Meta-Analysis version 2.0 software, the forest map was drawn, and the subgroup analysis was carried out. Results: a total of 13 studies on the risk of hepatitis C virus infection and coronary atherosclerotic diseases were included. The risk of coronary atherosclerotic diseases in patients with hepatitis C virus was 1.3 times as high as that in non-hepatitis C patients. According to the method of design, age, diabetes, hypertension and so on, the critical value of age is 50 years old, the critical value of diabetes is 20% of epidemic population, and the critical value of hypertension is 20% of epidemic population. It turned out to be 50 years old, The risk of coronary atherosclerotic heart disease in patients with hepatitis C virus was 1.2895 CI 1.04-1.59V P0.05, and the total risk OR of 50 years old was 1.3195% CI 0.94-1.82% P0.050.There was no significant difference between the two groups in the incidence of chronic hepatitis C with hypertension below 20%. The risk OR value of coronary atherosclerotic disease was 1.10 ~ 95 CI 0.60-1.82% P0.05 and P0.05, there was no statistical significance. The OR value of coronary atherosclerosis in more than 20% of patients with hepatitis C with hypertension was 1.390.95. The OR value of coronary atherosclerotic disease in patients with hepatitis C with diabetes was 1.15-1.66P0.05.20%, the OR value was 1.08c95 CI 0.60-1.96P0.05. The OR value of coronary atherosclerotic disease in more than 20% of hepatitis C patients with diabetes mellitus was 1.3595% and 1.08-1.68% (P 0.05). Conclusion: hepatitis C virus infection can significantly increase the risk of coronary atherosclerotic heart disease.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R512.63;R543.3

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