奥曲肽联合不同剂量垂体后叶素治疗血吸虫性肝硬化继发上消化道出血的应用研究

发布时间：2018-05-26 09:13

本文选题：奥曲肽 + 垂体后叶素　；参考：《中国地方病防治杂志》2016年04期

【摘要】：目的比较并探究奥曲肽联合不同剂量垂体后叶素治疗血吸虫性肝硬化继发上消化道出血的应用研究。方法106例消化科住院并进行治疗的血吸虫性肝硬化继发性上消化道出血的患者,随机分为对照组和观察组,各53例。对照组患者使用奥曲肽0.05mg/ml进行前期静脉推注,保持25μg/h维持静脉滴注的效果,保持0.5ml/min进行维持治疗。观察组患者奥曲肽联合垂体后叶素1U/ml静脉滴注0.5h左右,保持0.5ml/min进行维持治疗。比较两组患者的临床效果、止血效果以及不良反应发生的情况。结果两组患者总有效率比较差异无统计学意义(P0.05);两组的平均止血时间和止血量比较差异均无统计学意义(P0.05);观察组的不良反应发生率明显小于对照组(P0.05)。结论奥曲肽联合小剂量垂体后叶素治疗血吸虫性肝硬化继发上消化道出血不良反应较少,用药量较少,可在临床上进一步推广运用。
[Abstract]:Objective to compare and investigate the clinical application of octreotide combined with different doses of pituitrin in the treatment of upper gastrointestinal hemorrhage secondary to schistosomiasis cirrhosis. Methods 106 patients with secondary upper gastrointestinal bleeding due to schistosomiasis cirrhosis were randomly divided into control group and observation group with 53 cases each. Patients in the control group were treated with octreotide 0.05mg/ml to maintain the effect of intravenous infusion at 25 渭 g / h and maintenance therapy with 0.5ml/min. Patients in the observation group were treated with octreotide combined with pituitrin 1U/ml intravenous drip for 0.5 h to maintain 0.5ml/min. The clinical effect, hemostatic effect and adverse reaction were compared between the two groups. Results there was no significant difference in the total effective rate between the two groups (P 0.05), the mean hemostasis time and hemostasis volume were not significantly different between the two groups, and the incidence of adverse reactions in the observation group was significantly lower than that in the control group (P 0.05). Conclusion Octreotide combined with low dose of pituitrin in the treatment of secondary upper gastrointestinal hemorrhage due to schistosomiasis cirrhosis has fewer adverse reactions and less dosage, so it can be popularized in clinical practice.
【作者单位】：四川省广元市第一人民医院消化内科;
【分类号】：R575.2;R532.2

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