老年乙型肝炎患者肝硬化危险因素

发布时间：2018-05-28 15:41

本文选题：乙肝 + 肝硬化　；参考：《中国老年学杂志》2015年13期

【摘要】：目的探讨乙型肝炎老年患者肝硬化相关危险因素。方法乙肝后肝硬化老年患者150例为观察组,并随机选择未曾出现肝硬化的乙肝老年患者72例为对照组。观察肝硬化影响因素〔包括HBs Ag、HBe Ag、抗HBe阳性率、HBV DNA(105拷贝/ml)、合并HCV感染、乙肝病毒HBV天冬氨酸(YMDD)变异、饮酒的比例等〕,并对危险因素分析采用Logistic回归分析。结果观察组HBs Ag、HBe Ag、抗HBe阳性率、HBV DNA(105拷贝/ml)、合并HCV感染、HBV YMDD变异、饮酒(酒精20 g/d)的比例均显著高于对照组(P0.01);HBs Ag、抗HBe阳性率、HBV DNA(105拷贝/ml)、合并HCV感染、HBV YMDD变异、饮酒(酒精20 g/d)比例均是老年乙肝肝硬化的独立危险因素(P0.01)。结论老年乙肝患者出现肝硬化危险因素主要为活动性乙肝病毒复制及饮酒等,积极抗病毒治疗有望预防进展至肝硬化。
[Abstract]:Objective to investigate the risk factors of liver cirrhosis in elderly patients with hepatitis B. Methods 150 elderly patients with posthepatitic cirrhosis as observation group and 72 elderly patients without liver cirrhosis as control group were randomly selected as control group. The influencing factors of liver cirrhosis (including HBs Ag-HBe Ag, anti-HBV-positive rate and HBV DNA(105 copy / mil), HCV infection, hepatitis B virus HBV aspartic acid (HBV) YMDD mutation, drinking rate and so on were observed. Logistic regression analysis was used to analyze the risk factors. Results the positive rate of anti-HBe and anti-HBe in the observation group was significantly higher than that in the control group (P 0.01 / d), and the positive rate of anti-HBe was significantly higher than that of the control group. The positive rate of anti-HBe was significantly higher than that of the control group. Alcohol consumption (20 g / d) was an independent risk factor for hepatitis B cirrhosis in elderly patients (P 0.01). Conclusion the main risk factors of liver cirrhosis in elderly patients are active hepatitis B virus replication and drinking. Active antiviral therapy is expected to prevent liver cirrhosis.
【作者单位】：青海省第四人民医院急诊科;
【基金】：青海省全球抗击艾滋病、结核病和疟疾基金结核病项目(No.CHN-102-G02-T-00)
【分类号】：R512.62

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