2型糖尿病合并非酒精性脂肪肝与non-HDL、RBP、SF的关系

发布时间：2018-05-29 15:49

本文选题：型糖尿病 + 非酒精性脂肪肝　；参考：《暨南大学学报(自然科学与医学版)》2015年05期

【摘要】：目的:探讨2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)新的特点,以寻找新的治疗靶点.方法:选取106例T2DM患者,根据肝脏彩色B超结果,分为T2DM伴NAFLD(A组,64例),T2DM无NAFLD(B组,42例).收集两组患者的一般资料,检测血压(BP)、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(Hb A1c)、血清铁蛋白(SF)、视黄醇结合蛋白(RBP),计算体质量指数(BMI)、非高密度脂蛋白(non-HDL)、胰岛素抵抗指数(HOMA-IR),并进行相关分析,对两组患者进行体成分分析及眼底检查确定是否有糖尿病视网膜病变(DR).结果:两组相比,性别、年龄、血压、病程差异无统计学意义(P0.05),与B组相比,A组SF、BMI、non-HDL、HOMA-IR均明显升高,差异具有统计学意义(P0.05),A组内脏型肥胖发生率及DR发生率高,两组相比较差异具有统计学意义(P0.05).结论:T2DM合并NAFLD患者多存在内脏型肥胖、non-HDL代谢紊乱,体内存在明显的胰岛素抵抗、炎症反应及铁过载.T2DM患者如合并NAFLD更加容易发生糖尿病视网膜病变.
[Abstract]:Objective: to explore the new characteristics of type 2 diabetes mellitus (T2DM) combined with NAFLD and to find a new therapeutic target. Methods: according to the results of liver color B ultrasound, 106 patients with T2DM were divided into T2DM group and NAFLD(A group (n = 64). There were 42 cases without NAFLD(B in T2DM group. Collect the general data of the two groups of patients, Blood pressure (BP), fasting blood glucose (FBG), fasting plasma glucose (FPG), fasting insulin (FIN), glycosylated hemoglobin (HbA1cN), serum ferritin (SFN), retinol binding protein (RBP), body mass index (BMI), non-HDL (non-HDL), insulin resistance index (HOMA-IRR) were measured, and correlation analysis was carried out. Body composition analysis and fundus examination were performed to determine the presence of diabetic retinopathy. Results: there was no significant difference in sex, age, blood pressure and course of disease between the two groups (P 0.05). Compared with group B, the HOMA-IR in group A was significantly higher than that in group B, and the incidence of visceral obesity and Dr in group A was significantly higher than that in group A (P 0.05). The difference between the two groups was statistically significant (P 0.05). Conclusion the visceral obesity and non-HDL metabolic disorder are common in the patients with NAFLD, and there are obvious insulin resistance, inflammatory reaction and iron overload. NAFLD is more likely to develop diabetic retinopathy in the patients with T2DM than in the patients with T2DM.
【作者单位】：暨南大学附属第一医院内分泌科;右江民族医学院附属医院内分泌科;
【基金】：百色市科学研究与技术开发计划项目(20140942)
【分类号】：R587.1;R575.5

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