重症急性胰腺炎合并腹腔感染的易感因素及细菌药敏性分析

发布时间：2018-05-31 12:16

本文选题：重症急性胰腺炎 + 腹腔感染　；参考：《福建医科大学》2014年硕士论文

【摘要】：目的：回顾性分析我院5年来重症急性胰腺炎患者临床资料，找出同合并腹腔感染相关的易感因素，，并行细菌培养及药物敏感性分析，以便更好进行诊治与预防。方法：收集280例重症急性胰腺炎患者临床资料，分析合并感染与非合并感染组间有差异性指标并行Logistic回归分析，探讨其同重症急性胰腺炎合并腹腔感染的关系。收集重症急性胰腺炎合并腹腔感染腹水或坏死组织标本，并行细菌培养及药物敏感性分析。结果：器官功能衰竭数，腹腔积液，血钙，肠功能障碍是重症急性胰腺炎合并腹腔感染的易感因素。目前主要致病菌仍为革兰氏阴性菌。排名前两位的革兰氏阴性菌为大肠埃希菌，铜绿假单胞菌；排名前两位的革兰氏阳性菌为肠球菌，金黄色葡萄球菌。两类常见致病菌均对常用抗生素普遍不敏感。结论：临床上早期SAP合并腹腔感染的治疗需针对其易感因素以及常见致病菌谱，药物敏感性问题采取相应治疗措施，以增加临床治疗效果。
[Abstract]:Objective: to retrospectively analyze the clinical data of patients with severe acute pancreatitis (SAP) in our hospital in recent 5 years, and find out the susceptible factors associated with abdominal infection, bacteria culture and drug sensitivity analysis so as to make better diagnosis, treatment and prevention. Methods: the clinical data of 280 patients with severe acute pancreatitis were collected, and the relationship between the two groups was analyzed by Logistic regression analysis. Ascites or necrotic tissue specimens of severe acute pancreatitis complicated with abdominal infection were collected for bacterial culture and drug sensitivity analysis. Results: the number of organ failure, peritoneal effusion, blood calcium and intestinal dysfunction were the susceptible factors of severe acute pancreatitis complicated with abdominal infection. At present, the main pathogenic bacteria are still Gram-negative bacteria. The first two Gram-negative bacteria were Escherichia coli, Pseudomonas aeruginosa, and the first two Gram-positive bacteria were Enterococcus and Staphylococcus aureus. The two common pathogens are generally insensitive to common antibiotics. Conclusion: the clinical treatment of SAP with abdominal infection should be based on its susceptible factors, common pathogenic bacteria spectrum and drug sensitivity, so as to increase the effect of clinical treatment.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R576

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