炎性指标联合检测诊断急性胰腺炎继发感染的价值

发布时间：2018-06-01 14:07

本文选题：急性胰腺炎 + 感染　；参考：《中华医院感染学杂志》2015年04期

【摘要】：目的探讨降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)在急性胰腺炎(AP)继发感染诊断中的价值,减少全身炎性综合征的发生率。方法对2012年1月-2013年12月102例AP患者根据细菌培养结果分为感染组50例及非感染组52例,感染组再分为重度脓血症组18例及轻度脓血症组32例,两组均于入院第1、3、7、14天抽取血液标本,测量PCT、CRP、IL-6浓度。结果感染组第1、3天PCT阳性率为44.00%、20.00%,高于非感染组的25.00%、5.77%,差异有统计学意义(P0.05);第3、7、14天感染组PCT与非感染组比较差异有统计学意义(P0.05);感染组第1、3、7、14天IL-6与非感染组比较,差异有统计学意义(P0.05);感染组第1、3、7、14天CRP与非感染组比较差异有统计学意义(P0.05),但组内第3、7天IL-6、CRP水平与第1天比较,差异均无统计学意义,第14天水平均较第1天显著下降,差异有统计学意义(P0.05);重度脓血症组各时段PCT、CRP、IL-6水平均高于非重症脓血症组,差异有统计学意义(P0.05)。结论 PCT、CRP、IL-6联合检测对AP继发感染早期诊断有较高价值,其中PCT的诊断敏感度最高。
[Abstract]:Objective to investigate the diagnostic value of procalcitonin (PCT) C-reactive protein (CRP) and interleukin-6 (IL-6) in the secondary infection of acute pancreatitis (AP) and to reduce the incidence of systemic inflammatory syndrome (SPS). Methods from January 2012 to December 2013, 102 patients with AP were divided into infection group (n = 50) and non-infection group (n = 52) according to the results of bacterial culture. The infected group was divided into severe sepsis group (n = 18) and mild sepsis group (n = 32). The blood samples were collected on the 1st day of admission and the serum levels of IL-6 were measured in the two groups. Results the positive rate of PCT in the infected group was 44.00 and 20.00 on the 1st day, which was higher than that in the non-infected group (25.00 / 5.77), the difference was statistically significant (P0.05), the difference between the PCT of the infected group and the non-infected group on the 3rd day 714 was statistically significant (P 0.05), and the IL-6 of the infected group was higher than that of the non-infected group on the 13th day (P < 0.05), and the IL-6 of the infected group was higher than that of the non-infected group on day 13714. There was significant difference in the level of CRP between the infected group and the non-infected group on the 1st day (P 0.05), but on the 3rd day after infection, there was no significant difference in the level of IL-6 CRP between the first day and the first day, and the level on the 14th day was significantly lower than that on the first day. The level of IL-6 in patients with severe sepsis was significantly higher than that in patients with non-severe sepsis (P 0.05), and the level of IL-6 in patients with severe sepsis was significantly higher than that in patients with non-severe sepsis (P 0.05). Conclusion the combined detection of PCT and IL 6 is valuable in the early diagnosis of secondary infection of AP, and the sensitivity of PCT is the highest.
【作者单位】：新疆阿克苏市兵团第一师医院消化科;新疆阿克苏市兵团第一师医院儿科;张掖市人民医院病理科;
【基金】：新疆维吾尔自治区自然科学基金资助项目(No200121112)
【分类号】：R576

【参考文献】