血清和肽素对急性胰腺炎的诊断和预后判断作用

发布时间：2018-06-02 05:59

本文选题：急性胰腺炎 + 和肽素　；参考：《实用医学杂志》2015年16期

【摘要】：目的:观察急性胰腺炎(AP)患者血清中和肽素浓度的变化,探讨和肽素在(AP)诊断和预后判断中的作用。方法:63例AP患者入选,其中轻型急性胰腺炎(MAP)35例,重症急性胰腺炎(SAP)28例。研究对象于入院第1、2、3天抽血检测和肽素浓度,并收集临床病死率、局部并发症发生率数据进行分析。另以30例正常健康人的血清和肽素浓度作为对照。结果:AP患者就诊时血清和肽素浓度比正常健康人明显升高(P0.05)。SAP患者血清和肽素水平高于同时段的AP(P0.05)。SAP患者的血清和肽素浓度与患者死亡和局部并发症发生呈正相关(P0.01)。结论:和肽素在MAP患者起病早期即明显升高,并与疾病的严重程度密切相关,可以作为AP早期诊断和判断预后的血清学指标。
[Abstract]:Objective: to observe the changes of serum peptide concentration in patients with acute pancreatitis (AP), and to explore the role of heparin in the diagnosis and prognosis of acute pancreatitis (AP). Methods Sixty-three patients with AP were enrolled, including 35 cases of mild acute pancreatitis (AP) and 28 cases of severe acute pancreatitis (SAP). The blood samples and peptide concentration were measured on the 2nd day after admission, and the clinical mortality and the incidence of local complications were collected and analyzed. The concentrations of serum and peptide in 30 healthy subjects were used as control. Results the serum and peptide concentrations in patients with AP(P0.05).SAP were significantly higher than those in normal controls. The levels of serum and peptide in patients with AP(P0.05).SAP were significantly higher than those in patients with AP(P0.05).SAP at the same time. There was a positive correlation between the concentration of serum and peptide and the mortality and local complications of patients with AP. Conclusion: the level of propeptide increased significantly in the early stage of MAP and was closely related to the severity of the disease. It can be used as a serological index for early diagnosis and prognosis of AP.
【作者单位】：广东省开平市中心医院急诊科;中山大学附属第三医院胃肠外科;
【基金】：广东省自然科学基金资助(编号:S2013040016160)
【分类号】：R576

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