枳术宽中胶囊联合雷贝拉唑钠肠溶片治疗脾虚气滞证胃食管反流病50例

发布时间：2018-06-02 15:38

本文选题：反流性食管炎 + 枳术宽中胶囊　；参考：《中国实验方剂学杂志》2015年08期

【摘要】：目的:观察枳术宽中胶囊联合雷贝拉唑治疗脾虚气滞证胃食管反流病(GERD)的临床疗效及对生活质量的影响。方法:将100例患者采用随机按数字表法分为对照组和观察组各50例。两组均采用口服雷贝拉唑钠肠溶片,20 mg/次,早、晚各1次。对照组口服枸橼酸莫沙必利片,5 mg/次,3次/d。观察组口服枳术宽中胶囊,3粒/次,3次/d,两组疗程均为8周。进行治疗前后胃食管反流病问卷(Gerd Q),健康简单(SF-36)量表和脾虚气滞证评分。结果:经Ridit分析,治疗后观察组胃镜下炎症疗效和中医证候疗效均优于对照组(P0.05);治疗后观察组SF-36量表生理机能、生理职能、身体疼痛、总体健康、生命活力、精神健康、社会功能及情感职能等8个维度评分均高于对照组(P0.05);治疗后观察组Gerd Q评分和脾虚气滞证评分低于对照组(P0.05)。结论:枳术宽中胶囊联合雷贝拉唑钠肠溶片治疗能减轻GERD(脾虚气滞证)患者临床症状、体征,能提高患者生活质量,其临床疗效优于枸橼酸莫沙必利片。
[Abstract]:Objective: to observe the clinical effect of Zhizhukanzhong capsule combined with rabeprazole in the treatment of gastroesophageal reflux disease with spleen deficiency qi stagnation syndrome and its effect on quality of life. Methods: 100 patients were randomly divided into control group (n = 50) and observation group (n = 50). Both groups were treated with rabeprazole sodium enteric-coated tablets for 20 mg/, morning and evening. The control group was treated with oral mosapride citrate tablets for 5 mg/ d. The observation group was treated by oral administration of trifoliate capsules (3 capsules / 3 times / 3 times / d). The course of treatment in both groups was 8 weeks. Before and after treatment, GERD QN, SF-36) scale and spleen deficiency Qi stagnation scale were used in patients with gastroesophageal reflux disease (GERD) before and after treatment. Results: by Ridit analysis, the curative effect of gastroscope inflammation and TCM syndrome in the observation group was better than that in the control group (P 0.05), the physiological function, body pain, general health, vitality and mental health of the observation group were better than those of the control group. The scores of social function and emotional function were higher than that of control group (P 0.05), the scores of Gerd Q and spleen deficiency Qi stagnation in observation group were lower than those in control group (P 0.05). Conclusion: the treatment of Zhizhoukanzhong capsule combined with rabeprazole sodium enteric-coated tablets can relieve the clinical symptoms and signs of GERD and improve the quality of life of the patients, and its clinical curative effect is better than mosapride citrate tablets.
【作者单位】：遵义市第一人民医院;
【分类号】：R571

【参考文献】