聚乙二醇散联合双歧杆菌三联活菌散治疗老年功能性便秘的临床观察

发布时间：2018-06-03 08:12

本文选题：老年 + 功能性便秘　；参考：《中国药房》2015年09期

【摘要】：目的:观察聚乙二醇散联合双歧杆菌三联活菌散治疗老年功能性便秘的临床疗效和安全性。方法:将144例老年功能性便秘患者随机均分为A、B、C组。A组患者给予双歧杆菌三联活菌散1 g,B组患者给予聚乙二醇4000散10 g,C组患者给予双歧杆菌三联活菌+聚乙二醇4000散,于早、晚餐后口服。各组患者疗程均为4周。观察各组患者的临床疗效,药物起效时间,大便形态恢复正常时间,第2、4周大便次数,治疗前后各临床症状评分及不良反应发生情况。结果:C组患者总有效率显著高于A、B组,且药物起效时间及第2、4周大便次数均显著多于A、B组,大便形态恢复正常时间显著短于A、B组,差异均有统计学意义(P0.05)。治疗后各组患者各临床症状评分均显著低于同组治疗前,且C组低于A、B组,差异均有统计学意义(P0.05)。各组患者治疗期间均未见严重不良反应发生。结论:聚乙二醇散联合双歧杆菌三联活菌散较单用聚乙二醇散或双歧杆菌三联活菌散疗效更为显著,安全性较好。
[Abstract]:Objective: to observe the clinical efficacy and safety of polyethylene glycol powder combined with Bifidobacterium triple viable powder in the treatment of senile functional constipation. Methods: 144 senile patients with functional constipation were randomly divided into two groups: group A and group A were given bifidobacterium triplex viable bacteria powder 1 g / g B group and group B received polyethylene glycol 4000 powder 10 g / g C group, and the group A was treated with polyethylene glycol 4000 powder (P < 0.01). Take orally after dinner. The course of treatment was 4 weeks. The clinical curative effect, the time of effective drug, the time of returning to normal defecation, the number of defecation at the 2nd week, the clinical symptom score and the occurrence of adverse reaction before and after treatment were observed. Results the total effective rate of group C was significantly higher than that of group A, and the effective time and defecation frequency of group 2 were significantly higher than that of group A B, and the time of normal stool shape recovery was significantly shorter than that of group A (P 0.05). After treatment, the clinical symptom scores of each group were significantly lower than those of the same group before treatment, and C group was lower than Agna B group, the difference was statistically significant (P 0.05). No serious adverse reactions occurred during treatment. Conclusion: polyethylene glycol powder combined with Bifidobacterium triple active powder is more effective and safe than that of polyethylene glycol powder or bifidobacterium triple active powder alone.
【作者单位】：攀枝花市中心医院;
【分类号】：R574.62

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