永康地区幽门螺杆菌感染与耐药性分析

发布时间：2018-06-03 22:04

本文选题：幽门螺杆菌 + 感染　；参考：《中华医院感染学杂志》2016年10期

【摘要】：目的分析永康地区幽门螺杆菌的感染情况及对常用抗菌药物的耐药性,为临床治疗幽门螺杆菌感染提供参考依据。方法选取医院2014年1月-2015年1月由于上消化道不适进行胃镜检查的698例患者,经过尿素酶试验、过氧化氢酶试验、氧化酶试验以及革兰染色镜检测幽门螺杆菌感染率,采用E-test法,检测幽门螺杆菌对常用抗菌药物的耐药性;采用SPSS18.0软件对数据进行统计分析。结果 698份幽门螺杆菌胃黏膜标本中阳性246例,阳性率为35.2%;胃癌患者阳性率高于十二指肠炎、胃炎等患者,差异有统计学意义(P0.05);幽门螺杆菌对甲硝唑的耐药率比其他抗菌药物高,差异有统计学意义(P0.05)。结论永康地区幽门螺杆菌的感染率较高,与疾病的种类有一定的关系;幽门螺杆菌对甲硝唑和克拉霉素的耐药率菌较高,不宜选用,对阿莫西林和左氧氟沙星的耐药率较低,可作为治疗幽门螺杆菌感染的首选治疗药物。
[Abstract]:Objective to analyze the infection of Helicobacter pylori in Yongkang area and its resistance to common antimicrobial agents so as to provide reference for clinical treatment of Helicobacter pylori infection. Methods from January 2014 to January 2015, 698 patients with upper gastrointestinal tract discomfort were examined by urease test, catalase test, oxidase test and Gram staining microscope to detect the infection rate of Helicobacter pylori. The drug resistance of Helicobacter pylori to common antimicrobial agents was detected by E-test, and the data were analyzed by SPSS18.0 software. Results 246 of 698 gastric mucosa specimens of Helicobacter pylori were positive, the positive rate of gastric cancer was 35.22.The positive rate of gastric cancer was higher than that of duodenitis and gastritis. The resistance rate of Helicobacter pylori to metronidazole was higher than that of other antimicrobial agents (P 0.05). Conclusion the infection rate of Helicobacter pylori is higher in Yongkang area, which is related to the kinds of diseases, and the resistant rate of Helicobacter pylori to metronidazole and clarithromycin is higher than that to clarithromycin, and the resistant rate to amoxicillin and levofloxacin is low. It can be used as the first choice for the treatment of Helicobacter pylori infection.
【作者单位】：宁波开发区中心医院消化内科;金华第一人民医院消化内科;永康第一人民医院消化内科;
【基金】：浙江省医药卫生基金资助项目(2014KYB275)
【分类号】：R573

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