炎症小体活化与非病毒性肝病的研究进展

发布时间：2018-06-05 05:35

本文选题：肝疾病 + 炎症小体　；参考：《医学研究生学报》2017年05期

【摘要】：炎症小体是多种蛋白质组成的复合体,能感知受损的细胞及病原体产生的危险信号,从而激活半胱天冬酶1(caspase-1)使炎症因子白细胞介素1β(IL-1β)及IL-18/33释放出胞外。炎症小体的活化会造成肝细胞损伤、免疫细胞活化从而加重炎症反应。文章讨论炎症小体在不同肝疾病,如酒精性肝炎、非酒精性肝病、肝缺血再灌注损伤等发生发展中的作用。这些研究成果将进一步加深对非病毒性肝疾病发病机制的认识,为此类肝疾病的治疗提供新的思路。
[Abstract]:Inflammatory corpuscles, a complex of many proteins, can sense the dangerous signals produced by damaged cells and pathogens, thus activating cysteinase 1 and caspase-1) to release the inflammatory factor IL-1 尾 and IL-18/33 out of the cells. The activation of inflammatory corpuscles can result in liver cell injury and immune cell activation, thereby exacerbating the inflammatory response. This paper discusses the role of inflammatory bodies in the development of various liver diseases, such as alcoholic hepatitis, non-alcoholic liver disease and hepatic ischemia-reperfusion injury. These results will further deepen the understanding of the pathogenesis of non-viral liver diseases and provide new ideas for the treatment of such liver diseases.
【作者单位】：南昌大学第一附属医院消化内科;
【基金】：国家自然科学基金(81660110)
【分类号】：R575

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