高血压合并非酒精性脂肪肝患者糖代谢及其危险因素的临床研究

发布时间：2018-06-05 07:10

本文选题：原发性高血压 + 非酒精性脂肪肝　；参考：《现代预防医学》2015年05期

【摘要】：目的研究高血压合并非酒精性脂肪肝患者糖代谢情况,并探讨脂肪肝可能的危险因素。方法收集2 010例高血压患者一般临床资料,测量血压,身高,体重,腰围,臀围,测定空腹血糖,OGTT2h血糖,糖化血红蛋白,血脂,肌酐等指标,并行肝脏的腹部超声检查,从而将高血压病患者分为合并非酒精性脂肪肝组(647例)和单纯高血压组(1 463例)。结果 647例高血压合并非酒精性脂肪肝患者血糖调节异常的有218例,占33.38%,糖尿病有280例,占43.28%,单因素分析显示:年龄、高脂病史、肌酐、腰围、甘油三酯、HDL-C、2h餐后血糖、糖化血红蛋白在高血压合并非酒精性脂肪肝组与单纯高血压组之间差异有统计学意义(P0.05或P0.01),经多因素Logistic回归分析显示:OGTT2h血糖、高血脂病史、腰围、甘油三酯是高血压病患者发生脂肪肝的危险因素(OR值分别是1.10,5.81,1.03,1.16,P0.05),HDL-C是其保护因素(OR值是0.51,P0.05)。结论高血压合并非酒精性脂肪肝与肥胖,糖、脂质代谢异常等密切相关,相应患者我们应高度关注,采取综合措施进行早期干预和治疗。
[Abstract]:Objective to study the glucose metabolism in hypertensive patients with non-alcoholic fatty liver and explore the possible risk factors of fatty liver. Methods Clinical data of 2010 patients with hypertension were collected, blood pressure, height, weight, waist circumference and hip circumference were measured. Fasting blood glucose OGTT 2h blood glucose, glycosylated hemoglobin, blood lipid, creatinine were measured. The patients with hypertension were divided into two groups: 647 patients with nonalcoholic fatty liver and 1 463 patients with hypertension. Results among 647 patients with hypertension and non-alcoholic fatty liver, 218 cases (33.38%) had abnormal blood glucose regulation, 280 cases (43.28%) had diabetes mellitus. Univariate analysis showed that age, history of hyperlipidemia, creatinine, waist circumference, triglyceride HDL-C 2 h postprandial blood glucose, The difference of glycosylated hemoglobin between hypertension with non-alcoholic fatty liver group and simple hypertension group was significant (P0.05 or P0.01). The multivariate Logistic regression analysis showed that the blood glucose, history of hyperlipidemia, waist circumference and blood sugar of 2 h were found by multivariate Logistic regression analysis. The OR value of triglyceride as a risk factor for fatty liver in patients with hypertension was 1.105.81U 1.105.81U 1.16p 0.05N HDL-C, and the OR value was 0.51g / g P0.05g / L respectively. Conclusion Hypertension combined with non-alcoholic fatty liver is closely related to obesity, glucose and abnormal lipid metabolism. We should pay close attention to the patients and take comprehensive measures to carry out early intervention and treatment.
【作者单位】：四川泸州医学院附属医院内分泌科;四川泸州医学院附属医院心内科;
【基金】：中华医学会临床医学科研专项资金-施贵宝内分泌糖尿病研究项目[2012]96号
【分类号】：R544.1;R575.5

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