代谢综合征组分与非酒精性脂肪性肝病的关系

发布时间：2018-06-08 06:44

本文选题：代谢综合征X + 非酒精性脂肪性肝病　；参考：《中国全科医学》2015年17期

【摘要】：目的探讨代谢综合征(MS)组分与非酒精性脂肪性肝病(NAFLD)的关系,为MS不同组分患者防治NAFLD提供参考。方法选择2014年6月—2014年12月在天津医科大学总医院接受治疗的符合MS组分之一及以上的患者344例,将患者按照是否符合MS诊断标准,分为MS组和非MS组;同时,又按照MS组分数目进行分组,满足其中1项组分为组1,满足2项组分为组2,满足3项组分为组3,全部满足为组4。抽取患者空腹静脉血,检测空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、血尿酸(SUA)和24 h微量清蛋白尿(MAU)。患者均行上腹部肝脏超声检查,判定是否患有NAFLD。结果两组性别、年龄、FPG及Hb A1c比较,差异均无统计学意义(P0.05)。MS组体质指数(BMI)、收缩压(SBP)、舒张压(DBP)、TC、TG、SUA、MAU、NAFLD患病率均高于非MS组,HDL-C低于非MS组(P0.05)。随着代谢异常组分的增多,BMI、SBP、DBP、TG、SUA、NAFLD患病率逐渐增高,HDL-C水平逐渐下降(P0.01)。Logistic回归分析结果显示,BMI和TG是NAFLD发生的独立危险因素(P0.05)。结论患者BMI、TG和MS组分数目与NAFLD关系密切,监测这些指标有助于早期发现NAFLD高危人群。
[Abstract]:Objective to investigate the relationship between the components of metabolic syndrome (MS) and NAFLD in patients with nonalcoholic fatty liver disease (NAFLD), and to provide reference for the prevention and treatment of NAFLD in patients with MS with different components. Methods 344 patients who were treated in Tianjin Medical University General Hospital from June 2014 to December 2014 were divided into MS group and non-MS group according to whether they met the diagnostic criteria of MS. According to the number of MS components, one of them was divided into group 1, two groups were divided into group 2, three groups were divided into group 3, and all of them were satisfied as group 4. Fasting venous blood samples were collected to detect fasting blood glucose (FPG), glycosylated hemoglobin (HbA1cN), total cholesterol (TC), triglyceride (TGN), high density lipoprotein cholesterol (HDL-CU), serum uric acid (SUAA) and 24 h microalbuminuria (MAU). All patients underwent upper abdominal liver ultrasonography to determine whether they had NAFLD. Results there was no significant difference in body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP) between the two groups in FPG and HbA1c. The prevalence of NAFLD in both groups was higher than that in non-MS group (P 0.05). With the increase of abnormal components of metabolism, the prevalence rate of NAFLD increased gradually and the level of HDL-C decreased gradually. Logistic regression analysis showed that BMI and TG were independent risk factors of NAFLD. Conclusion there is a close relationship between the number of BMIT TG and MS components and NAFLD. Monitoring these indexes is helpful for early detection of high risk population of NAFLD.
【作者单位】：天津医科大学总医院内分泌科;
【分类号】：R589;R575.5

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