脂肪肝相关危险因素的评估

发布时间：2018-06-09 12:18

本文选题：脂肪肝 + 危险因素　；参考：《福建医科大学》2014年硕士论文

【摘要】：目的探讨脂肪肝发病的相关危险因素。方法选取2013.9-11月具有完整资料的福建省立医院体检中心的健康体检者1000例，排除恶性肿瘤、病毒性肝炎标志物阳性、慢性胰腺炎、严重肾功损伤、急性感染或创伤、长期激素应用史，通过问卷调查、体格检查、实验室检测及腹部超声检查对脂肪肝组的年龄、性别、体重指数、血压、血糖、血脂、血尿酸、肝功能、血常规及有无胆石症与非脂肪肝组进行对比分析。结果 1000例体检者中，，超声诊断出脂肪肝416例（41.6%），其中男性287例（51.9%），女性129例（28.9%），二者检出率间差异有统计学意义（χ=54.011，P0.05）；脂肪肝组超重、肥胖、糖代谢紊乱、高血压、血脂异常、高尿酸血症的患病率高于非脂肪肝组，差异有统计学意义（P0.05）。单因素分析显示，脂肪肝组体重指数、收缩压、舒张压、甘油三酯、总胆固醇、低密度脂蛋白、空腹血糖、尿酸等均高于非脂肪肝组，差异有统计学意义（P0.05），而高密度脂蛋白胆固醇则低于非脂肪肝组，差异亦有统计学意义（P0.05）。多因素Logistic回归结果显示年龄、性别（男性）、体重指数、甘油三酯、低密度脂蛋白、空腹血糖6项指标进入了回归方程（P0.05）。结论超重、肥胖、高血压、糖代谢紊乱、血脂异常、高尿酸血症都增加了脂肪肝的患病风险。年龄、性别、体重指数、甘油三酯、低密度脂蛋白、空腹血糖是脂肪肝发病的危险因素。
[Abstract]:Objective to investigate the risk factors of fatty liver disease. Methods 1000 healthy persons from Fujian Provincial Hospital physical examination Center from September to November 2013.were selected to exclude malignant tumor, positive markers of viral hepatitis and chronic pancreatitis. Severe renal injury, acute infection or trauma, long history of hormone use, age, sex, body mass index, blood pressure, blood glucose, blood lipid, serum uric acid in fatty liver group by questionnaire, physical examination, laboratory and abdominal ultrasound, The liver function, blood routine, cholelithiasis and non-fatty liver were compared and analyzed. There were 41.6 cases of fatty liver diagnosed by ultrasound, of which 287 cases were male (51.9%), 129 cases were female (28.9%), the difference between them was statistically significant (蠂 ~ (2 +) 54.011) (P 0.05), fatty liver group was overweight, obesity, disorder of glucose metabolism, hypertension, abnormal blood lipid. The prevalence of hyperuricemia was higher than that of non-fatty liver (P 0.05). Univariate analysis showed that body mass index, systolic blood pressure, diastolic blood pressure, triglyceride, total cholesterol, low density lipoprotein, fasting blood glucose and uric acid in fatty liver group were higher than those in non-fatty liver group. The difference was statistically significant (P 0.05), and high density lipoprotein cholesterol (HDL-C) was significantly lower than that in non fatty liver group (P 0.05). The results of multivariate logistic regression showed that age, sex (male, body mass index, triglyceride, low density lipoprotein, fasting blood glucose) entered the regression equation (P 0.05). Conclusion overweight, obesity, hypertension, disorder of glucose metabolism, dyslipidemia, and hyperlipidemia were found in the regression equation. Hyperuricemia increases the risk of fatty liver disease. Age, sex, body mass index, triglyceride, low density lipoprotein, fasting blood glucose are risk factors for fatty liver.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R575.5

【参考文献】