青岛地区汉族人群脂联素基因多态性与非酒精性脂肪性肝病的相关性

发布时间：2018-06-12 17:37

本文选题：脂肪肝 + 非酒精性　；参考：《实用医学杂志》2015年09期

【摘要】：目的:探讨青岛地区汉族人群脂联素(ADIPOQ)基因rs266729和rs2241766两位点的多态性与非酒精性脂肪性肝病(NAFLD)的相关性。方法:采用多聚酶链反应(PCR)及基因型检测的方法对青岛地区汉族人群338例NAFLD患者(NAFLD组)和280例正常人群(对照组)进行基因型的检测,采用Pearsonχ2检验、Logistic回归分析、t检验等方法对各组基因型、等位基因以及临床资料进行比较。结果:脂联素rs266729位点基因型及等位基因频率在NAFLD组与对照组之间存在明显差异(χ2=9.929,P=0.007;χ2=9.809,P=0.002)。校正混杂因素后,G等位基因携带者患NAFLD的风险是C等位基因的1.41倍(OR=1.410,95%CI:1.082~1.831,P=0.008)。而rs2241766基因型及等位基因在两组中未见明显差异(χ2=0.327,P=0.849;χ2=0.074,P=0.785)。结论 :在青岛地区汉族人群中,脂联素基因rs266729G等位基因携带者罹患NAFLD的风险增加,而rs2241766基因多态性与NAFLD的发病无明显相关性。
[Abstract]:Objective: to investigate the relationship between the polymorphism of adiponectin (ADIPOQ) gene rs266729 and rs2241766 and NAF LDD in Qingdao Han population. Methods: the genotypes of 338 NAFLD patients and 280 normal controls were detected by polymerase chain reaction (PCR) and genotypic detection. The genotypes, alleles and clinical data of each group were compared by Pearson 蠂 2 test and logistic regression analysis. Results: the genotypes and allelic frequencies of adiponectin rs266729 locus were significantly different between NAFLD group and control group (蠂 2 9. 929 P 0. 007; 蠂 2 9. 809 P 0. 002). After adjusting for confounding factors, the risk of NAFLD in G allele carriers was 1.41 times higher than that in C alleles. The risk of NAFLD was 1.41 times higher than that of C alleles. The risk of NAFLD was 1.41 times higher than that of C alleles. However, there was no significant difference in genotype and allele of rs2241766 between the two groups (蠂 2, 0.327, P < 0. 849; 蠂 2, 0. 074, P < 0. 785). Conclusion: the allele carriers of adiponectin gene rs266729G have an increased risk of NAFLD in Qingdao Han population, but the polymorphism of rs2241766 gene has no significant correlation with the occurrence of NAFLD.
【作者单位】：南京医科大学青岛临床医学院;山东省青岛市市立医院消化内二科;
【基金】：国家自然科学基金资助项目(编号:81170337) 青岛市民生科技计划项目(编号:14-2-3-17-nsh)
【分类号】：R575.5

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