血浆输注治疗非甾体抗炎药相关性消化性溃疡并出血的临床转归回顾性研究

发布时间：2018-06-13 14:10

本文选题：消化性溃疡 + 非甾体抗炎药　；参考：《中国输血杂志》2017年05期

【摘要】：目的探讨血浆输注对非甾体抗炎药(NSAIDs)相关性消化性溃疡并出血的临床转归影响。方法收集本院NSAIDs相关性消化性溃疡并出血病例97例,根据是否曾输注血浆分为实验组:56例输注红细胞和血浆;对照组:41例仅输注红细胞;分析2组病例的一般临床资料、输血量、输血后疗效、临床转归相关指标。结果实验组与对照组比较:1)2组的性别、年龄、休克发生率、溃疡大小、溃疡Forrest分级、合并症、输血后Hb等无明显差异(P0.05);2)PT、APTT(s)在输血前分别为20.30±2.65 vs 19.76±2.07(P0.05)、49.70±2.93 vs 46.93±5.10(P0.05),在输血后分别为13.12±1.68 vs 18.13±1.80(P0.05)、31.67±5.06 vs 40.41±2.64(P0.05);实验组输血前、后凝血功能差异明显(P0.05),而对照组变化基数(P0.05);3)平均红细胞输注量(m L)分别为420±63.75 vs 673±55.62(P0.05),好转率分别为91.0%(51/56)vs 73.2%(30/41)(P0.05),平均住院时间(d)分别为6.37±2.15 vs11.21±3.07(P0.05),再出血率分别为5.4%vs 19.5%(P0.05)。结论早期输注血浆既可及时纠正NSAIDs相关性消化性溃疡并出血患者凝血功能,又能有效减少患者红细胞输注用量,缩短患者平均住院时间,有助于更好的临床转归预后。
[Abstract]:Objective to investigate the effect of plasma infusion on the clinical outcome of non-steroidal anti-inflammatory drugs (NSAIDs)-associated peptic ulcer and hemorrhage. Methods 97 cases of NSAIDs associated peptic ulcer with bleeding were collected and divided into experimental group (n = 56) and control group (n = 41). The quantity of blood transfusion, the curative effect after blood transfusion, and the related indexes of clinical outcome. Results the sex, age, incidence of shock, ulcer size, ulcers Forrest grade and complications were compared between the experimental group and the control group. After blood transfusion, there was no significant difference in HB (20.30 卤2.65 vs 19.76 卤2.07 vs 49.70 卤2.93 vs 46.93 卤5.10 P0.05) before blood transfusion, 13.12 卤1.68 vs 18.13 卤1.80 P0.05V before blood transfusion vs 31.67 卤5.06 vs 40.41 卤2.64P0.05in the experimental group, respectively. The difference of blood coagulation function was significant (P 0.05), while the mean RBC infusion volume of the control group was 420 卤63.75 vs 673 卤55.62% P0.05L, respectively. The improvement rate was 91.0%(51/56)vs 73.2% 30% P 0.05, the average hospitalization time was 6.37 卤2.15 vs11.21 卤3.07 vs11.21 P 0.05L, and the rate of rebleeding was 5.4%vs 19.5T P 0.05U, and the average hospitalization time was 6.37 卤2.15 vs11.21 卤3.07g / P0.05a, respectively, and the average time of hospitalization was 6.37 卤2.15 vs11.21 卤3.07g / P0.05g / L, respectively, and the average time of hospitalization was 6.37 卤2.15 vs11.21 卤3.07g / P0.05a, respectively. Conclusion early infusion of plasma can not only correct the coagulation function of patients with NSAIDs associated peptic ulcer and bleeding, but also reduce the amount of erythrocyte transfusion and shorten the average hospitalization time of patients, which is helpful to the prognosis of patients with NSAIDs associated peptic ulcer.
【作者单位】：南昌大学第一附属医院输血科;
【基金】：江西省科技重大项目(20144BBG70001)
【分类号】：R457.1;R573.1

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