消化性溃疡出血患者外周血骨代谢指标的水平与幽门螺杆菌感染的关系

发布时间：2018-06-13 19:04

本文选题：消化性溃疡 + 出血　；参考：《中华医院感染学杂志》2015年06期

【摘要】：目的探讨消化性溃疡出血患者血清Ⅰ型胶原氨基端前肽(PINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)的水平变化及与幽门螺杆菌(Hp)感染的关系。方法选择2011年1月-2013年12月80例消化性溃疡患者为观察组,分为溃疡出血组50例和溃疡组30例,选择36名健康者为对照组,检测受试人员血清中PINP、β-CTX含量,并对各指标与年龄、病程、临床症状、Hp感染等关系进行相关性分析。结果观察组患者血清PINP、β-CTX含量明显低于对照组,差异有统计学意义(P0.01);溃疡出血组患者血清PINP、β-CTX水平明显低于溃疡组和对照组(P0.05),溃疡组血清PINP、β-CTX含量低于对照组(P0.05);Hp阳性患者血清PINP、β-CTX含量低于Hp阴性患者(P0.05)。结论 PINP、β-CTX在消化性溃疡出血患者血清中呈低表达;PINP、β-CTX在消化性溃疡出血中的表达与患者Hp感染状况有关。
[Abstract]:Objective to investigate the changes of serum levels of type I collagen aminoterminal prepeptide 尾 (尾 -CTX) in patients with peptic ulcer hemorrhage and its relationship with Helicobacter pylori (HP) infection. Methods from January 2011 to December 2013, 80 patients with peptic ulcer were divided into two groups: ulcer bleeding group (n = 50), ulcer group (n = 30) and control group (n = 36). The correlation between the course of disease and the clinical symptoms of HP infection was analyzed. Results the serum levels of PINP, 尾 -CTX in the observation group were significantly lower than those in the control group. The serum levels of PINPand 尾 -CTX in ulcer bleeding group were significantly lower than those in ulcer group and control group (P 0.05), and the levels of serum PINP and 尾 -CTX in ulcer group were lower than those in control group (P 0.05) and 尾 -CTX level was lower than that in HP negative group (P 0.05). Conclusion the expression of PINP, 尾 -CTX in serum of patients with peptic ulcer hemorrhage is low. The expression of 尾 -CTX in peptic ulcer haemorrhage is related to HP infection.
【作者单位】：浙江省舟山医院门诊内科;浙江省舟山医院内镜科;
【基金】：浙江省医药卫生科技计划基金资助项目(2012kyb143)
【分类号】：R573

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