急性胰腺炎患者血浆PTX3水平与早期炎症反应及病情严重程度的关系

发布时间：2018-06-15 23:06

  本文选题：正五聚蛋白 + 急性胰腺炎　； 参考：《山东医药》2016年22期

【摘要】：目的探讨急性胰腺炎(AP)患者血浆正五聚蛋白3(PTX-3)水平与早期炎症反应及严重程度的关系。方法选择AP患者62例,其中轻度32例(MAP组)、中度18例(MSAP组)、重度12例(SAP组)。另择同期健康体检者25例作为对照组。检测血浆PTX3及炎性因子IL-6、IL-8、TNF-α,采用APACHEⅡ评分、Ranson评分评估病情严重程度,Pearson相关分析血浆PTX3与炎性因子、APACHEⅡ评分、Ranson评分的相关性。结果 AP患者入院时血浆PTX3均高于对照组;以SAP组最高,MSAP组次之,MAP组最低(P均0.01)。SAP组血浆IL-6、IL-8、TNF-α及APACHEⅡ评分、Ranson评分均高于MSAP组和MAP组,MSAP组高于MAP组(P均0.01)。血浆PTX3与IL-6、IL-8、TNF-α及APACHEⅡ评分、Ranson评分均呈显著正相关(r分别为0.726、0.908、0.899、0.780、0.620,P均0.05)。结论血浆PTX3在AP患者早期炎症程度、病情严重程度评估方面具有一定的应用价值,有可能成为SAP早期诊断和预后判断的指标之一。
[Abstract]:Objective to investigate the relationship between plasma normal pentagglutinin 3 (PTX-3) level and early inflammatory reaction in patients with acute pancreatitis (AP). Methods 62 cases of AP were selected, including 32 cases of mild map group, 18 cases of moderate MSAP group and 12 cases of severe SAP group. Another 25 healthy persons were selected as control group. Plasma PTX3 and IL-6 IL-8 TNF- 伪 were detected. The correlation between plasma PTX3 and inflammatory factor Apache 鈪，

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