幽门螺杆菌感染与胃息肉关系的Meta分析

发布时间：2018-06-16 05:14

本文选题：胃息肉 + 幽门螺杆菌　；参考：《山东医药》2015年44期

【摘要】：目的分析幽门螺杆菌(Hp)感染与胃息肉的相关性。方法检索从建库至2015年4月Pub Med、Embase、中国生物医学文献数据库、中国知网、万方期刊数据库、维普数据库内收录的Hp感染与胃息肉关系的病例对照研究。由两位研究者按照纳入与排除标准筛选文献,提取资料和评价纳入研究质量后,采用Rev Man5.3及STATA11.0软件进行Meta分析。结果共纳入12个病例对照研究,总样本量4 453例,其中胃息肉组2 009例、对照组2 444例。Meta分析结果显示,胃息肉组Hp感染率与对照组相比差异无统计学意义(OR=0.86,95%CI:0.44~1.66,P=0.650);胃底腺息肉患者Hp阳性率与对照组相比差异有统计学意义(OR=0.32,95%CI:0.15~0.68,P=0.004)。敏感性分析显示结果较为稳定。结论当前证据不足以证明Hp感染与胃息肉有关。
[Abstract]:Objective to analyze the correlation between Helicobacter pylori (HP) infection and gastric polyps. Methods A case-control study on the relationship between HP infection and gastric polyps in the database of Pub Meden Embase, Chinese Biomedical Literature Database, China Journal Database, Wanfang Journal Database and Weip Database was conducted. According to the inclusion and exclusion criteria, the two researchers sifted the literature, extracted the data and evaluated the quality of the study, and then carried out Meta-analysis by using the software Rev Man5.3 and STATA11.0. Results in 12 case-control studies, the total sample size was 4 453 cases, including 2 009 cases in gastric polyp group and 2 444 cases in control group. There was no significant difference in HP infection rate between the gastric polyp group and the control group. There was no significant difference in HP infection rate between the gastric polyp group and the control group. There was no significant difference between the HP infection rate of the gastric polyp group and that of the control group, and the positive rate of HP in the patients with gastric fundus polyp was significantly higher than that in the control group. Sensitivity analysis showed that the results were stable. Conclusion the current evidence is not sufficient to prove that HP infection is associated with gastric polyps.
【作者单位】：遵义医学院附属医院贵州省消化疾病研究所;遵义医学院;遵义医学院第三附属医院;
【基金】：贵州省科技厅社会发展攻关项目[黔科合SY字(2011)3056号]
【分类号】：R573

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