加味补中益气汤联合奥美拉唑肠溶胶囊治疗老年反流性食管炎的疗效及对生活质量和复发情况的影响

发布时间：2018-06-21 11:35

本文选题：加味补中益气汤 + 奥美拉唑　；参考：《中国老年学杂志》2017年22期

【摘要】：目的研究加味补中益气汤联合奥美拉唑肠溶胶囊对老年反流性食管炎(RE)患者疗效及生活质量、复发情况的影响。方法采用前瞻性研究法,选取老年RE患者96例,随机将其分为对照组及研究组,每组48例。对照组给予常规西药治疗,在此基础上,研究组加施加味补中益气汤治疗,两组均连续治疗4 w。比较两组治疗效果、不良反应、复发情况,同时比较两组治疗前后生活质量、食管黏膜氧化应激指标及胃肠激素指标。结果研究组治疗总有效率(87.50%)明显高于对照组(68.75%,χ~2=4.94,P=0.03);治疗后,研究组胃动素(MTL)、胃泌素(GAS)均显著高于对照组(P0.05);研究组总超氧化物歧化酶(T-SOD)水平明显高于对照组,丙二醛(MDA)明显低于对照组(P0.05);研究组治疗后6个月复发率显著低于对照组(χ~2=5.03,P=0.02)。同时,两组不良反应发生率无显著差异(P0.05)。结论加味补中益气汤联合奥美拉唑对RE患者的临床效果显著,能够明显改善患者食管黏膜氧化应激反应和胃肠激素表达,同时可有效提高生活质量,降低复发率。
[Abstract]:Objective to study the effect of modified Buzhong Yiqi decoction combined with omeprazole enteric coated capsule on the quality of life and relapse in elderly patients with reflux esophagitis. Methods 96 elderly patients with RE were randomly divided into control group (n = 48) and study group (n = 48). The control group was treated with routine western medicine. On this basis, the study group was treated with modified Buzhong Yiqi decoction, both of which were treated continuously for 4 weeks. The quality of life (QOL), esophageal mucosal oxidative stress index and gastrointestinal hormone index before and after treatment were compared between the two groups. Results the total effective rate (87.50) in the study group was significantly higher than that in the control group (68.75), 蠂 ~ (2 +) was 24.94% (P < 0.05). After treatment, the motilin (MTL) and gastrin (gastrin) in the study group were significantly higher than those in the control group (P 0.05), and the levels of total superoxide dismutase (T-SOD) in the study group were significantly higher than those in the control group. The MDAs of malondialdehyde (MDA) were significantly lower than those of the control group (P 0.05), and the recurrence rate of the study group was significantly lower than that of the control group at 6 months after treatment (蠂 2 + 5.03). At the same time, there was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion the clinical effect of Jiawei Buzhong Yiqi decoction combined with omeprazole on RE patients is remarkable. It can obviously improve the oxidative stress reaction of esophageal mucosa and the expression of gastrointestinal hormones, at the same time, it can effectively improve the quality of life and reduce the recurrence rate.
【作者单位】：长治医学院附属和济医院中医科;长治医学院附属和济医院普外科;
【基金】：山西省高等学校科技创新项目(20131110)
【分类号】：R571

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