肠易激综合征的静息态脑fMRI及VBM研究

发布时间：2018-06-24 07:15

本文选题：肠易激综合征 + 功能磁共振　；参考：《长江大学》2017年硕士论文

【摘要】：目的:应用静息态功能磁共振成像(RS-fMRI)分析技术及基于体素的全脑形态学测量技术(VBM)研究静息状态下肠易激综合征(IBS)患者脑功能及结构的改变,有利于深层次的理解IBS的发病机制。材料和方法:纳入收治于荆州市第一人民医院消化内科的17例IBS患者及年龄、性别比例、受教育年限相匹配的17例健康对照组为研究对象,采用Philips Achieva 3.0T多源磁共振扫描仪于静息状态下对所有受试者行静息态血氧水平依赖功能磁共振(BOLD-fMRI)和三维脑结构磁共振检查。应用比率低频振幅(fALFF)、局部一致性(Re Ho)方法分析静息态下脑功能活动状况,运用基于体素的全脑形态学测量技术(VBM)探讨全脑灰质体积的改变。经统计学处理后获得IBS患者静息状态下脑功能及脑结构改变的特异性脑区。结果:1、fALFF分析:相对于正常对照组,在静息状态下IBS患者左侧眶部额上回fALFF值升高,右侧壳、左侧岛叶、左侧缘上回fALFF值减低,差异有统计学意义(P0.005)。2、Re Ho分析:相对于正常对照组,在静息状态下IBS患者左侧颞中回Re Ho值升高,右侧颞横回、右侧岛叶、右侧中央前回Re Ho值减低,差异有统计学意义(P0.005)。3、VBM分析:IBS组较正常对照组左侧中央旁回、右侧中央后回、双侧楔前叶、双侧海马、左侧眶部额中回灰质体积增高,右侧颞上回、左侧岛盖部额下回、小脑蚓部灰质体积减低,差异有统计学意义(P0.005)。结论:1、IBS在静息状态下多个脑区存在神经元活动强度和整体活动同步性的异常,提示IBS存在广泛的脑功能异常。2、IBS存在广泛的脑结构异常,既有部分脑区灰质体积的减小,也有部分脑区灰质体积的增加。3、利用比率低频振幅(fALFF)、局部一致性(Re Ho)及基于体素的形态学(VBM)的方法能有效的评价IBS在静息状态下脑功能状况和形态学的改变,研究中枢神经系统在IBS中作用。
[Abstract]:Objective: to study the changes of brain function and structure in patients with irritable bowel syndrome (IBS) under resting state by means of resting functional magnetic resonance imaging (RS-fMRI) and voxel based whole brain morphology measurement (VBM). It is helpful to understand the pathogenesis of IBS. Materials and methods: seventeen patients with IBS treated in Department of Digestive Medicine of the first people's Hospital of Jingzhou and 17 healthy controls matched by age, sex ratio and years of education were included in the study. The resting oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) and three-dimensional brain structure magnetic resonance imaging (Mr) were performed in all subjects by Philips Achieva 3.0T multisource magnetic resonance scanner. The ratio low frequency amplitude (fALFF) and local consistency (re Ho) were used to analyze the brain function in resting state. The changes of gray matter volume in the whole brain were studied by VBM based on voxel. The specific areas of brain function and brain structure of IBS patients were obtained after statistical treatment. Results compared with the normal control group, the fALFF value in the left suprafrontal gyrus of IBS patients increased, while the fALFF values in the right shell, the left insular lobe and the left superior margin gyrus decreased. The difference was statistically significant (P0.005) .2Re Ho analysis: compared with the normal control group, the FALFF value of the left orbital superior frontal gyrus in IBS patients was significantly higher than that in the normal control group. The re Ho value in the left middle temporal gyrus increased, the right transverse temporal gyrus, the right insular lobe and the right precentral gyrus decreased under resting condition. The difference was statistically significant (P 0.005) .3VBM analysis showed that the left central paracentral gyrus and the right posterior central gyrus in the control group were significantly higher than those in the control group. The volume of gray matter in bilateral anterior cuneate lobe, bilateral hippocampus, left orbital middle frontal gyrus, right superior temporal gyrus, left inferior frontal gyrus and cerebellar vermis decreased significantly (P 0.005). Conclusion there are abnormal neuronal activity intensity and global synchronism in several brain regions under resting state, suggesting that IBS has extensive abnormal brain structure and reduced gray matter volume in some brain regions. There was also an increase in the volume of gray matter in some brain regions. The methods of ratio low frequency amplitude (fALFF), local consistency (re Ho) and voxel based morphology (VBM) could be used to evaluate the brain function and morphological changes of IBS in resting state. To study the role of central nervous system in IBS.
【学位授予单位】：长江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R574.4

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