丙型肝炎肝硬化患者预后相关危险因素分析

发布时间：2018-06-24 18:12

  本文选题：肝炎 + 丙型　； 参考：《实用医学杂志》2015年09期

【摘要】：目的:评价影响丙型肝炎肝硬化患者预后的相关危险因素。方法:对我院2002-2011年期间收治的丙肝肝硬化患者资料进行研究,并对其进行规律随访。首先对各潜在预后相关危险因素与生存情况或肝移植情况的关系分别进行单因素分析,再将其有统计学意义的指标分别纳入Logistic回归及COX回归模型。结果:共纳入572例丙肝患者,其中143例合并肝硬化,男103例(72.03%),平均年龄59(51~71)岁。在143例肝硬化患者中,57例(39.86%)患有糖尿病,41例(28.67%)有大量饮酒史,3例(2.10%)存在HBV感染。经统计分析发现,终末期肝病评分≥10分、糖尿病及合并HBV感染与无肝移植生存期有明显相关性(P0.05),糖尿病与腹水、细菌感染及肝性脑病明显相关(P0.05)。随访分析发现糖尿病与肝病腹水进展、细菌感染、肾功能紊乱及肝癌有明显相关性(P0.05)。结论:糖尿病是丙肝肝硬化患者预后的独立危险因素,控制糖尿病有可能提高该类患者的生存质量。
[Abstract]:Objective: to evaluate the risk factors associated with the prognosis of patients with hepatitis C cirrhosis. Methods: the data of patients with cirrhosis of hepatitis C admitted from 2002 to 2011 in our hospital were studied and followed up regularly. First, univariate analysis was carried out on the relationship between each potential prognostic risk factor and survival condition or liver transplantation condition, and then the statistically significant indexes were included in logistic regression and Cox regression models. Results: a total of 572 patients with hepatitis C were included, 143 of whom were complicated with cirrhosis, 103 males (72.03%), with an average age of 59 years (51 / 71). Of 143 patients with liver cirrhosis, 57 (39.86%) had diabetes mellitus, 41 (28.67%) had heavy drinking history and 3 (2.10%) had HBV infection. Statistical analysis showed that the score of end-stage liver disease 鈮，

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