肝硬化合并门静脉血栓形成危险因素的Meta分析

发布时间：2018-06-26 18:04

  本文选题：肝硬化 + 门静脉血栓　； 参考：《山西医科大学》2017年硕士论文

【摘要】：目的:系统评价肝硬化合并门静脉血栓形成的相关危险因素,为肝硬化患者门静脉血栓的防治提供参考依据。方法:计算机检索PubMed、Cochrane Library、EMBASE、Science Direct、中国知网、维普、CBM、万方数据库中与肝硬化合并门静脉血栓形成相关的中、英文文献,并辅以人工检索、文献追溯等方法同时检索,检索时间截止到2016年8月。之后由两位研究者独立对所选文献进行数据提取及质量评价,并采用Stata 14.0软件进行数据分析。结果:所得文献经过去重、通读全文逐步剔除后,最终纳入21项符合标准的病例对照研究,共2854例患者。其中发生门静脉血栓的患者871例,血栓发生率为30.6%。Meta分析结果显示:肝硬化门静脉血栓的形成与门静脉流速(WMD=-1.725,95%CI:-2.064~-1.386)、门静脉主干直径(WMD=1.684,95%CI:1.486~1.882)、脾脏厚度(WMD=6.478,95%CI:5.580~7.376)、血小板(WMD=-8.605,95%CI:-10.797~-6.414)、血浆D-二聚体水平(WMD=2.488,95%CI:2.088~2.889)、PTHR G20210A基因(OR=4.586,95%CI:1.881~11.182)以及糖尿病(WMD=1.833,95%CI:1.291~2.603)等有关;与患者的性别、年龄、肝功能、吸烟、饮酒、高血压、凝血酶原时间、白细胞计数等无关。结论:在本Meta分析纳入的参数中,脾脏厚度、门静脉流速、门静脉主干直径、血小板计数、血浆D-二聚体水平、PTHR G20210A基因、糖尿病史是肝硬化合并门静脉血栓形成的主要因素,而患者基本状况、肝功、凝血酶原时间等指标与门静脉血栓形成无直接相关性。
[Abstract]:Objective: to evaluate the risk factors of portal vein thrombosis in cirrhotic patients and to provide reference for prevention and treatment of portal vein thrombosis in cirrhotic patients. Methods: the Chinese and English literatures related to portal vein thrombosis associated with cirrhosis and portal vein thrombosis were searched by computer in PubMedus Cochrane Library EMBASE Science DirectNet, CBM, Wanfang database, and were retrieved simultaneously by manual search and literature tracing. The search time is up to August 2016. After that, two researchers carried out the data extraction and quality evaluation independently, and analyzed the data by Stata 14.0 software. Results: 2854 patients were included in 21 Case-control studies. Among them, 871 patients with portal vein thrombosis, 琛，

本文编号：2070930