多指标联合检测在肝硬化合并感染诊断中的价值
发布时间：2018-06-27 07:16
本文选题：降钙素原 + 白介素 ； 参考：《第二军医大学学报》2015年10期
【摘要】：目的分析降钙素原(PCT)、白介素6(IL-6)、C-反应蛋白(CRP)、中性粒细胞CD64、白细胞计数(WBC)、中性粒细胞比例等多种指标联合检测诊断肝硬化患者合并感染的临床价值。方法将肝硬化住院患者按照细菌培养结果和临床症状分为感染组和非感染组,血清PCT、IL-6采用化学发光分析仪进行检测,血清CRP采用生化分析仪进行检测,中性粒细胞CD64采用流式细胞分析仪进行检测,WBC和中性粒细胞比例采用全血细胞分析仪进行检测。数据采用logistic回归和受试者工作特征(ROC)曲线进行分析。结果感染组各项指标均高于非感染组(P0.01)。Logistic回归分析结果表明PCT、IL-6和中性粒细胞CD64具有预测肝硬化合并感染的能力,其OR值分别为7.199(95%CI:2.180~23.771)、1.010(95%CI:1.002~1.017)和2.312(95%CI:1.485~3.600);而CRP、WBC和中性粒细胞比例不具有预测价值。ROC曲线分析结果显示,PCT、IL-6和中性粒细胞CD64的曲线下面积(AUC)分别为0.791(95%CI:0.727~0.856)、0.762(95%CI:0.693~0.832)和0.884(95%CI:0.835~0.933);三者联合检测的AUC为0.932(95%CI:0.897~0.967),诊断准确率为86.9%。结论PCT、IL-6和中性粒细胞CD64可以作为诊断肝硬化合并感染的指标,三者联合检测能够提高临床诊断效率。
[Abstract]:Objective to analyze the clinical value of combined detection of procalcitonin (PCT), interleukin-6 (IL-6) C-reactive protein (CRP), neutrophil CD64, white blood cell count (WBC) and neutrophil ratio in patients with cirrhosis. Methods the inpatients with liver cirrhosis were divided into infection group and non-infection group according to the bacterial culture results and clinical symptoms. The serum PCTX IL-6 was detected by chemiluminescence analyzer, and the serum CRP was detected by biochemical analyzer. Neutrophil CD64 was detected by flow cytometry and the ratio of neutrophil to neutrophil was detected by whole blood cell analyzer. The data were analyzed by logistic regression and operating characteristics (Roc) curves. Results all the indexes in infected group were higher than those in non-infected group (P0.01). Logistic regression analysis showed that PCTIL 6 and neutrophil CD64 had the ability to predict liver cirrhosis complicated with infection. 鍏禣R鍊煎垎鍒负7.199(95%CI:2.180~23.771),1.010(95%CI:1.002~1.017)鍜，
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