中性粒细胞CD64、CD32指数在肝硬化并自发性细菌性腹膜炎诊断中的价值

发布时间：2018-06-29 03:46

本文选题：肝硬化 + 自发性细菌性腹膜炎　；参考：《中国免疫学杂志》2015年06期

【摘要】：目的:探讨肝硬化患者腹水中性粒细胞CD32指数(n CD32 ID)、中性粒细胞CD64指数(n CD64 ID)和血清C反应蛋白(CRP)在肝硬化并自发性细菌性腹膜炎(SBP)中的诊断价值。方法:采用回顾性分析方法对入选的156例肝硬化患者进行腹水CD32、CD64流式检测及血清CRP检测,检测结果进行受试者特征曲线(ROC)分析。结果:SBP组n CD32 ID、n CD64 ID和CRP均明显高于非SBP组(P0.001),ROC曲线分析结果显示n CD32 ID、n CD64 ID和CRP的敏感性和特异性分别为:82.8%、96.2%、72.5%和81.0%、95.8%、73.1%。结论:n CD64 ID与n CD32 ID和CRP相比在诊断肝硬化并发自发性细菌性腹膜炎中具有更高的敏感性和特异性,是一种较好的肝硬化并自发性细菌性腹膜炎的早期鉴别诊断指标。
[Abstract]:Objective: to investigate the diagnostic value of ascitic neutrophil CD32 index (nCD32 ID), neutrophil CD64 ID (nCD64 ID) and serum C-reactive protein (CRP) in patients with cirrhosis and spontaneous bacterial peritonitis (SBP). Methods: a retrospective analysis was performed on 156 patients with liver cirrhosis by flow cytometry of ascites CD32U CD64 and determination of serum CRP. The results were analyzed by the characteristic curve of subjects (ROC). Results the sensitivity and specificity of n CD32 IDU n CD64 ID and CRP were 72.5% and 81.0%, respectively. The results of ROC curve analysis showed that the sensitivity and specificity of n CD32 IDP64 ID and CRP were 72.5% and 81.0%, respectively, compared with those in non-SBP group (P0.001). The sensitivity and specificity of n CD32 IDN ID and CRP were 72.5% and 81.0%, respectively. Conclusion compared with n-CD32ID and CRP, the ratio of w / n CD64ID is more sensitive and specific in the diagnosis of cirrhosis complicated with spontaneous bacterial peritonitis, and it is a good early differential diagnosis index of cirrhosis with spontaneous bacterial peritonitis.
【作者单位】：河北省沧州市中心医院核医学科;河北省沧州市中心医院中心实验室;河北省沧州市中心医院消化内科;
【分类号】：R575.2;R572.2

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