康复新液加双料喉风散灌肠联合美沙拉秦缓释颗粒口服对溃疡性结肠炎患者主要症状的影响

发布时间：2018-06-30 19:48

本文选题：溃疡性结肠炎 + 康复新液　；参考：《中医杂志》2015年23期

【摘要】：目的比较康复新液加双料喉风散灌肠联合美沙拉秦缓释颗粒口服与单纯美沙拉秦缓释颗粒口服治疗溃疡性结肠炎患者的疗效。方法将60例溃疡性结肠炎患者随机分为试验组和对照组各30例,对照组口服美沙拉秦缓释颗粒,每日4次,每次1 g;治疗组在对照组基础上以双料喉风散2.2 g加入康复新液50 ml及生理盐水150 ml每晚保留灌肠。两组均连续治疗1个月,分别于治疗前及治疗后1、2、3、4周时对患者主要症状腹泻、便脓血、腹痛、里急后重进行评分,并采用重复测量方差分析法进行分析,以症状评分作为因变量,观测时点作为时间因素,组别作为自变量纳入重复测量方差分析模型。结果腹泻、便脓血、腹痛、里急后重观测时点数据均不符合球形假设,给予校正。校正及组间效应方差分析提示,腹泻、便脓血、腹痛、里急后重评分均随观测时间的推移而显著减少,且治疗组症状评分均明显低于对照组(P0.05)。结论康复新液加双料喉风散灌肠联合美沙拉秦缓释颗粒口服与单纯美沙拉秦缓释颗粒口服均可改善溃疡性结肠炎患者主要临床症状,且前者改善效果更佳。
[Abstract]:Objective to compare the efficacy of Kangfeng liquid and Shuangshuifeng Powder enema combined with Mesalazine sustained release granules in the treatment of ulcerative colitis. Methods 60 patients with ulcerative colitis were randomly divided into two groups: the experimental group (n = 30) and the control group (n = 30). The treatment group was treated with 2. 2 g Shuangliaofeng powder and 50 ml of rehabilitation solution and 150 ml of normal saline every night in the treatment group. The two groups were treated continuously for one month. The main symptoms of diarrhea, empyema, abdominal pain, and acute and severe pain were evaluated before and after treatment for 4 weeks, and the results were analyzed by means of repeated measurement of variance. Symptom score was taken as dependent variable, observation time point as time factor, group as independent variable, and repeated measurement ANOVA model. Results the data of diarrhea, sepsis, abdominal pain and reobservation were not in accordance with the spherical hypothesis. Correction and ANOVA showed that diarrhea, purulent blood, abdominal pain, and acute weight scores were significantly decreased with the passage of observation time, and the symptom scores of the treatment group were significantly lower than those of the control group (P0.05). Conclusion the main clinical symptoms of patients with ulcerative colitis can be improved by the combination of Shuangshuifeng San enema combined with Mesalazin sustained release granules and meisalazine sustained-release granules alone, and the effect of the former is better.
【作者单位】：河南省中医院;北京中医药大学;天津中医药大学附属武清中医院;四川科伦药业股份有限公司;
【分类号】：R574.62

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