生长抑素联合丹参治疗肝硬化并发上消化道出血与门静脉血栓形成的临床研究

发布时间：2018-07-02 13:28

本文选题：生长抑素 + 丹参　；参考：《中国现代医学杂志》2017年13期

【摘要】：目的探讨生长抑素联合丹参对肝硬化并发上消化道出血(UGB)与门静脉血栓(PVT)形成的疗效作用。方法选取2010年1月-2016年1月在华北理工大学附属医院和唐山市传染病院住院的肝硬化并发UGB与PVT形成的患者96例。随机分为对照组24例,给予对症支持治疗;生长抑素组24例,给予对症支持治疗+生长抑素;丹参组24例,给予对症支持治疗+丹参;联合治疗组24例,给予对症支持治疗+生长抑素+丹参。观察4组患者治疗后丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、胆碱酯酶(CHE)、肝功能Child评分、凝血酶原时间(PT)、纤维蛋白原(FIB)、血小板(PLT)、门静脉内径(PVD)的变化及临床症状改善情况。结果生长抑素组、丹参组、联合治疗组ALT、AST、CHE、肝功能Child评分、PT、FIB、PLT、PVD与对照组相比,差异有统计学意义(P0.05),以联合治疗组降低最为明显;联合治疗组与生长抑素组、丹参组比较,差异有统计学意义(P0.05)。结论联合应用生长抑素和丹参治疗肝硬化并发上消化道出血与门静脉血栓形成有较好协同作用,疗效优于单纯西药治疗。
[Abstract]:Objective to investigate the therapeutic effect of somatostatin combined with salvia miltiorrhiza (Salvia miltiorrhiza) on upper gastrointestinal hemorrhage (UGB) and portal vein thrombosis (PVT) in patients with liver cirrhosis. Methods 96 patients with liver cirrhosis complicated with UGB and PVT were selected from January 2010 to January 2016 in affiliated Hospital of North China University of Technology and Tangshan Infectious Disease Hospital. They were randomly divided into control group (n = 24) receiving symptomatic support therapy, somatostatin group (n = 24), salvia miltiorrhiza group (n = 24) and combined treatment group (n = 24). Treatment of somatostatin salvia miltiorrhiza with symptomatic support. The changes of alanine aminotransferase (alt), aspartate aminotransferase (AST), cholinesterase (che), liver function Child score, prothrombin time (PT), fibrinogen (FIB), platelet (PLT), portal vein diameter (PVD) and the improvement of clinical symptoms were observed. Results compared with the control group, the somatostatin group, the salvia miltiorrhiza group and the combined treatment group had significant differences in alt ASTCHE and Child score of liver function (P 0.05), especially in the combined treatment group, the combination treatment group, the somatostatin group, and the salvia miltiorrhiza group were significantly lower than those in the control group, and there were significant differences between the combined treatment group, the somatostatin group and the Salvia miltiorrhiza group. The difference was statistically significant (P0.05). Conclusion combined use of somatostatin and salvia miltiorrhiza in the treatment of liver cirrhosis complicated with upper gastrointestinal hemorrhage and portal vein thrombosis has a good synergistic effect and the curative effect is better than that of western medicine alone.
【作者单位】：华北理工大学附属医院血液科;新疆巴州轮台县人民医院内一科;华北理工大学附属医院消化内科;河北省唐山市传染病院肝病科;
【分类号】：R573.2;R575.2

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