血管生成素与急性胰腺炎相关性的研究进展

发布时间：2018-07-03 16:10

本文选题：急性胰腺炎 + 血管生成素　；参考：《山东医药》2017年28期

【摘要】：血管生成素(Ang)是一族选择性作用于血管内皮的分泌型血管生长因子。Ang-1、Ang-2是Ang家族的成员,是特征性的血管生长因子,与机体的炎症反应及免疫功能密切相关。Ang-2与Ang-1的结构差别在于氨基端的卷曲螺旋结构域与羧基端的纤维蛋白样结构域交界处,前者比后者少了一个半胱氨酸,从而导致二者的生物学作用截然不同。当机体发生急性重症胰腺炎时,外周血Ang-2水平明显升高,在判断急性胰腺炎的严重程度、器官功能衰竭的发生及预后评估等方面具有重要价值。而Ang-1具有抗炎及改善血管渗漏作用,或许可作为炎症反应治疗的潜在靶点。随着对Ang研究的深入,未来其在临床中的应用价值将会更大。
[Abstract]:Angiopoietin (Ang) is a group of secretory vascular growth factors.Ang-1 that selectively acts on vascular endothelium. Ang-2 is a member of the Ang family. It is a characteristic vascular growth factor. It is closely related to the inflammatory response and immune function of the body. The structural difference between.Ang-2 and Ang-1 lies in the curl spiral domain and the carboxyl end fibers of the amino terminal. At the junction of the protein like domain, the former is less one cysteine than the latter, which leads to a distinct biological effect of the two. In the case of severe acute pancreatitis, the level of Ang-2 in the peripheral blood is significantly higher. It is of great value in judging the severity of acute pancreatitis, the occurrence of organ dysfunction and the evaluation of the prognosis. And Ang-1 has the potential for anti-inflammatory and improved vascular leakage or as a potential target for the treatment of inflammatory reactions. With the in-depth study of Ang, the future of its clinical application will be greater.
【作者单位】：南京医科大学鼓楼临床医学院;
【分类号】：R576

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