Cajal间质细胞自噬与STC关系的研究进展

发布时间：2018-07-05 19:24

  本文选题：慢传输型便秘 + Cajal间质细胞　； 参考：《山东医药》2016年40期

【摘要】：慢传输型便秘(STC)的发病机制目前尚未完全明确。胃肠道的运动取决于胃肠道的肌电活动。慢波是胃肠道肌电活动的起步电位,决定胃肠道平滑肌收缩的节律,是胃动力的基础。Cajal间质细胞(ICC)是胃肠道慢波活动的起搏细胞,可控制胃肠道的运动功能,其异常变化与STC发病有关。自噬是细胞程序性死亡的方式之一,适当自噬对营养缺乏状态下的细胞具有保护作用,过度自噬会诱导细胞发生Ⅱ型程序性细胞死亡,引起自噬性凋亡。ICC过度自噬可导致胃肠道肌电活动异常,可能是STC发生的关键因素之一。
[Abstract]:The pathogenesis of slow transit constipation (STC) is not fully understood. The movement of the gastrointestinal tract depends on the myoelectric activity of the gastrointestinal tract. Slow wave is the starting potential of gastrointestinal myoelectric activity, which determines the rhythm of gastrointestinal smooth muscle contraction. It is the basis of gastric motility. Cajal interstitial cells (ICC) are pacemaker cells of gastrointestinal slow wave activity, which can control the motility of gastrointestinal tract. The abnormal changes of STC were related to the pathogenesis of STC. Autophagy is one of the ways of programmed cell death. Proper autophagy has protective effect on the cells in the condition of nutrition deficiency. Excessive autophagy can induce the death of type 鈪，

本文编号：2101462