肠道菌群失调介导酒精性肝病发生发展的机制研究进展

发布时间：2018-07-06 16:21

本文选题：肠道菌群 + 酒精性肝病　；参考：《中国药理学通报》2016年04期

【摘要】：酒精性肝病是一种慢性进行性疾病,严重影响患者健康。在一般情况下,肠道菌群处于动态平衡,维持肠道正常生理功能。当机体长期摄入酒精后,酒精及其代谢物通过引起肠道菌群数量改变、肠道通透性增加、细菌位移等方式造成肠道菌群紊乱,从而激活机体免疫应答,诱导肝脏产生促炎症因子,促进酒精性肝病发生发展。而补充益生菌或益生元调节肠道菌群紊乱可以有效的改善酒精性肝病的临床指征,提示调节肠道菌群失调将会成为临床治疗酒精性肝病行之有效的手段。该文就近年来国内外关于酒精摄入、肠道菌群失调、酒精性肝病之间的相互关系及调节菌群紊乱治疗酒精性肝病的进展进行概述,为菌群失调与酒精性肝病的研究和治疗提供理论参考。
[Abstract]:Alcoholic liver disease is a chronic progressive disease, seriously affecting the health of patients. In general, intestinal flora is in dynamic balance and maintains normal intestinal physiological function. When the body ingested alcohol for a long time, alcohol and its metabolites caused intestinal microflora disorder by causing changes in the number of intestinal flora, increased intestinal permeability and bacterial displacement, thereby activating the immune response of the body. Induce liver to produce pro-inflammatory factors, promote the development of alcoholic liver disease. Supplementation of probiotics or probiotics to regulate intestinal flora disorder can effectively improve the clinical indications of alcoholic liver disease, suggesting that regulation of intestinal dysbacteriosis will become an effective method for the treatment of alcoholic liver disease. In this paper, the relationship between alcohol intake, intestinal flora disorder, alcoholic liver disease and the treatment of alcoholic liver disease were reviewed. To provide a theoretical reference for the study and treatment of dysbacteriosis and alcoholic liver disease.
【作者单位】：中国医药工业研究总院;上海医药工业研究院创新药物与制药工艺国家重点实验室;上海市生物物质成药性评价专业技术服务中心;
【基金】：国家自然科学基金资助项目(No81370564)
【分类号】：R575

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