实时组织弹性与血清学诊断肝硬化效能的比较

发布时间：2018-07-11 17:45

  本文选题：弹性成像技术 + 肝硬化　； 参考：《第二军医大学学报》2015年09期

【摘要】：目的比较实时组织弹性(real-time tissue elastography,RTE)技术、血清学检验诊断肝硬化的诊断价值,探讨临床非侵入性诊断肝硬化的优效方法。方法回顾性分析我院行肝切除手术或肝穿刺活检术住院患者的临床资料(n=124),收集病理学结果、RTE检查和血清学检验资料。RTE用肝纤维化指数(LFI)表示;血清学检验分为直接指标和间接指标,直接指标为肝脏纤维化四项(肝纤四项),包括透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C);间接指标为天冬氨酸转氨酶与血小板计数的比值(AST-to-platelet ratio index,APRI)。以病理诊断为金标准,绘制ROC曲线比较RTE和血清指标对肝硬化的诊断效能。结果 124例患者中非肝硬化组93例(75.0%),肝硬化组31例(25.0%)。以病理结果作为金标准,HA的诊断敏感度为67.7%,特异度为62.4%,准确度为63.7%;APRI指数的诊断敏感度为80.6%,特异度为49.5%,准确度为58.3%;LFI的诊断敏感度为93.5%,特异度为71.0%,准确度为76.6%。结论 LFI、HA、APRI指数对肝硬化均具有诊断价值,其中RTE测定的LFI诊断效能最高,APRI指数具有较高的敏感度但特异度最低。
[Abstract]:Objective to compare the diagnostic value of real-time tissue elastography (RTE) technique with serological examination in the diagnosis of liver cirrhosis and to explore the effective method of clinical non-invasive diagnosis of cirrhosis. Methods the clinical data of inpatients undergoing hepatectomy or biopsy were analyzed retrospectively. The pathological results and serological data were collected. The RTE was expressed by the liver fibrosis index (LFI). Serological tests are divided into direct and indirect indicators, The direct indexes were liver fibrosis (HA), laminin (LN), procollagen 鈪，

本文编号：2116082