自拟兰术化浊汤治疗溃疡性结肠炎临床疗效探讨及对血清炎性细胞因子水平的影响

发布时间：2018-07-13 15:05

【摘要】：目的:探讨自拟兰术化浊汤治疗溃疡性结肠炎临床疗效及对血清炎症因子指标的影响。方法:研究对象选取医院2013年1月—2014年12月收治溃疡性结肠炎患者80例,采用随机数字表法分为对照组和治疗组,每组各40例;其中对照组患者采用奥沙拉嗪钠单用治疗;治疗组患者则在对照组基础上加用自拟兰术化浊汤治疗;比较两组患者临床疗效,治疗前后临床症状积分、炎性细胞因子指标水平及临床复发率等。结果:对照组和治疗组患者治疗总有效率分别为77.50%(31/40),95.00%(38/40);治疗组患者临床疗效显著优于对照组,差异有统计学意义(P0.05);对照组患者治疗前后临床症状积分分别为(4.88±0.97)分,(4.06±0.73)分;治疗组患者治疗前后临床症状积分分别为(4.82±0.95)分,(3.15±0.50)分;治疗组患者治疗后临床症状积分显著低于对照组、治疗前,差异有统计学意义(P0.05);对照组患者治疗前后TNF-α水平分别为(65.33±6.24)ng/L,(59.07±4.37)ng/L;对照组患者治疗前后IL-8水平分别为(79.64±8.62)ng/L,(68.71±6.62)ng/L;治疗组患者治疗前后TNF-α水平分别为(65.28±6.19)ng/L,(51.25±2.98)ng/L;治疗组患者治疗前后IL-8水平分别为(79.87±8.58)ng/L,(60.54±4.37)ng/L;治疗组患者治疗后炎性细胞因子指标水平显著低于对照组、治疗前,差异有统计学意义(P0.05);对照组与治疗组患者随访复发率分别为17.50%(7/40),5.00%(2/40);治疗组患者临床复发率显著低于对照组,差异有统计学意义(P0.05)。结论:自拟兰术化浊汤治疗溃疡性结肠炎可有效缓解临床症状体征,改善炎性因子指标水平,且有助于降低复发风险。
[Abstract]:Objective: to investigate the clinical effect of Lanzaohuazhuo decoction in the treatment of ulcerative colitis and its influence on serum inflammatory cytokines. Methods: from January 2013 to December 2014, 80 patients with ulcerative colitis were randomly divided into control group (n = 40) and treatment group (n = 40). The patients in the treatment group were treated with the self-made Lanzaohuazhuo decoction on the basis of the control group, and the clinical efficacy, the clinical symptom score, the level of inflammatory cytokines and the clinical recurrence rate were compared between the two groups. Results: the total effective rate was 77.50% (31 / 40) or 95.00% (38 / 40) in the control group and the treatment group respectively, the clinical effect of the treatment group was significantly better than that of the control group (P0.05), the clinical symptom score of the control group was (4.88 卤0.97) points before and after treatment, (4.06 卤0.73) points. The scores of clinical symptoms were (4.82 卤0.95) and (3.15 卤0.50) before and after treatment in the treatment group, and the scores of the patients in the treatment group were significantly lower than those in the control group before and after treatment. The levels of TNF- 伪 were (65.33 卤6.24) ng / L, (59.07 卤4.37) ng / L before and after treatment in the control group, (79.64 卤8.62) ng / L, (68.71 卤6.62) ng / L in the control group, (65.28 卤6.19) ng / L, (51.25 卤2.98) ng / L before and after treatment in the treatment group, respectively. (79.87 卤8.58) ng / L, (60.54 卤4.37) ng / L; the levels of inflammatory cytokines in the treatment group were significantly lower than those in the control group. Before treatment, the difference was statistically significant (P0.05); the follow-up recurrence rate of the control group and the treatment group were 17.50% (7 / 40) or 5.00% (2 / 40); the clinical recurrence rate of the treatment group was significantly lower than that of the control group, the difference was statistically significant (P0.05). Conclusion: the treatment of ulcerative colitis with Lanzaohuazhuo decoction can effectively relieve the clinical symptoms and signs, improve the level of inflammatory factors, and help to reduce the risk of recurrence.
【作者单位】：杭州师范大学附属医院中西医结合内科;
【分类号】：R574.62

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