幽门螺杆菌感染对鹿城区高氨血症和肝性脑病发病的影响分析

发布时间：2018-07-14 18:10

【摘要】：目的探讨幽门螺杆菌(Hp)对鹿城区高氨血症和肝性脑病发病的影响。方法回顾性分析我院2013年6月~2015年6月60例住院肝硬化患者临床资料,并检测患者Hp和血氨水平及肝性脑病症状、数字连接试验结果等。Hp阳性者采用Hp三联根治疗法治疗1周,并于1个月后复查空腹下血氨水平,采用快速尿素酶试验检测其Hp感染情况。结果 60例肝硬化住院患者,其中Hp感染者为37例,占61.7%;肝性脑病者为28例,占46.7%。肝性脑病和亚临床肝性脑病及肝硬化无肝性脑病患者发生Hp感染率分别为75.0%(21/28)、66.7%(10/15)、29.4%(5/17);比较差异有统计学意义(P0.05);肝性脑病和亚临床肝性脑病及肝硬化无肝性脑病患者血氨水平分别为(95.1±51.2)μmol/L、(60.2±19.8)μmol/L、(47.5±14.6)μmol/L,比较差异有统计学意义(P0.05);经Logistic回归分析发现,血氨水平、上消化道出血、Child-Pugh、肝肾综合征及血红蛋白量为肝性脑病发生危险因素。结论根治Hp可有利于临床预防及治疗肝硬化肝性脑病。
[Abstract]:Objective to investigate the effect of Helicobacter pylori (HP) on hyperammonia and hepatic encephalopathy in Lucheng District. Methods the clinical data of 60 inpatients with liver cirrhosis from June 2013 to June 2015 were retrospectively analyzed. HP and blood ammonia levels and hepatic encephalopathy symptoms were detected. The results of digital connection test were used to treat the patients with HP triple radical therapy for 1 week. After one month, the blood ammonia level was reexamined and HP infection was detected by rapid urease test. Results among the 60 inpatients with liver cirrhosis, 37 cases (61.7%) were infected with HP and 28 cases (46.7%) with hepatic encephalopathy. The infection rate of HP in patients with hepatic encephalopathy, subclinical hepatic encephalopathy and cirrhosis without hepatic encephalopathy was 75.0% (21 / 28), 66.7% (10 / 15) or 29.4% (5 / 17), respectively, and the difference was statistically significant (P0.05). The mean values were (95.1 卤51.2) 渭 mol / L, (60.2 卤19.8) 渭 mol / L, (47.5 卤14.6) 渭 mol / L, respectively (P0.05). Blood ammonia level, upper gastrointestinal hemorrhage Child-Pugh, hepatorenal syndrome and hemoglobin content were risk factors of hepatic encephalopathy. Conclusion radical therapy of HP may be beneficial to the prevention and treatment of hepatic encephalopathy of liver cirrhosis.
【作者单位】：温州市鹿城区人民医院内科;温州市中心医院消化内科;
【分类号】：R575.2

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