低分子右旋糖酐联合吲哚美辛栓剂预防内镜逆行胰胆管造影术后胰腺炎

发布时间：2018-07-18 11:22

【摘要】：目的探讨低分子右旋糖酐联合吲哚美辛栓剂对内镜逆行胰胆管造影术(ERCP)后胰腺炎的预防作用。方法 215例至少具备一项ERCP术后胰腺炎高危因素的患者术前随机分为四组。对照组(n=51)给予氯化钠注射液+安慰剂,吲哚美辛组(n=54)给予氯化钠注射液+吲哚美辛栓剂(术前单次经直肠给药50 mg),低分子右旋糖酐组(n=52)给予低分子右旋糖酐(术前单次静脉输注500 m L)+安慰剂,药物联用组(n=58)给予低分子右旋糖酐(术前单次静脉输注500 m L)+吲哚美辛栓剂(术前单次经直肠给药50 mg)。观察术后胰腺炎发生率、重症急性胰腺炎发生率及患者死亡率,记录住院时间。结果对照组、吲哚美辛组、低分子右旋糖酐组和药物联用组胰腺炎发生率分别为24%、15%、14%和5%,药物联用组ERCP术后胰腺炎发生率低于对照组(P0.01);四组患者重症胰腺炎发生率以及死亡率无显著差异(P0.05)。对照组、吲哚美辛组、低分子右旋糖酐组和药物联用组平均住院时间分别为(5.8±2.9)、(5.2±1.9)、(6.1±2.5)和(4.3±2.0)d,与其他三组相比,药物联用组术后平均住院时间缩短(P0.05)。结论低分子右旋糖酐联合吲哚美辛栓剂对于ERCP术后胰腺炎有较好的预防作用。
[Abstract]:Objective to investigate the preventive effect of low molecular dextran and indomethacin suppository on pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Methods 215 patients with at least one risk factor of pancreatitis after ERCP were randomly divided into four groups. The control group (nf51) was given a placebo of sodium chloride injection. Indomethacin group (nnt54) was treated with sodium chloride injection indomethacin suppository (50 mg), before rectal administration) and low-molecular-weight dextran group (nf52) with low molecular weight dextran (500ml intravenously before operation) as a placebo. The combined drug group (nong58) was given low-molecular-weight dextran (500ml intravenously before operation) with indomethacin suppository (50 mg). Before single transrectal administration). The incidence of postoperative pancreatitis, the incidence of severe acute pancreatitis and the mortality of patients were observed, and the hospitalization time was recorded. Results the control group, indomethacin group, The incidence of pancreatitis in the low molecular dextran group and the combined drug group was 24 15% and 5%, respectively. The incidence of ERCP postoperative pancreatitis in the combined drug group was lower than that in the control group (P0.01), but there was no significant difference in the incidence and mortality of severe pancreatitis among the four groups (P0.05). The average hospitalization time of control group, indomethacin group, low molecular weight dextran group and drug combination group were (5.8 卤2.9), (5.2 卤1.9), (6.1 卤2.5) days and (4.3 卤2.0) days, respectively. Compared with the other three groups, the average hospitalization time of the combined drug group was shorter than that of the other three groups (P0.05). Conclusion low-molecular dextran combined with indomethacin suppository can prevent pancreatitis after ERCP.
【作者单位】：重庆医科大学附属第一医院第一分院消化内科;重庆医科大学附属第一医院消化内科;
【分类号】：R576

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